Effect of thyroid function status in hemodialysis patients on erythropoietin resistance and interdialytic weight gain

Thyroid function abnormalities are common in hemodialysis (HD) patients. Here, we investigated their frequency and impact on intradialytic hemodynamics and erythropoietin resistance index (ERI). Demographic and laboratory data including thyroid-stimulating hormone (TSH), interdialytic weight gain, a...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2018-11, Vol.29 (6), p.1274-1279
Main Authors: Bin Salih, Salih, Naji, Maryam Nasir, al-Tayyib, Abd Allah A., Hujayli, Fayiz Falih, al-Sayyari, Abd Allah Ahmad
Format: Article
Language:English
Subjects:
Anemia
Binding sites
Diabetes
Drug resistance
Erythropoietin
Health aspects
Hemodialysis
Hemodialysis patients
Hormones
Hypertension
Hyperthyroidism
Hypothyroidism
Proteins
Thyroid function tests
Thyroid gland
Transplants & implants
Weight gain
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Summary:Thyroid function abnormalities are common in hemodialysis (HD) patients. Here, we investigated their frequency and impact on intradialytic hemodynamics and erythropoietin resistance index (ERI). Demographic and laboratory data including thyroid-stimulating hormone (TSH), interdialytic weight gain, and intradialytic blood pressure (BP) changes were measured, and ERI was calculated. The prevalence and causes of abnormities in TSH and free thyroxine (FT4) and their effects on ERI and intradialytic hemodynamics were then assessed. One hundred and thirty patients (mean age, 57.1 ± 19.2 years; 66.4% diabetic, 86.7% hypertensive) were enrolled. Among them, 16.7% had hypothyroidism, 2.3% had hyperthyroidism, and 10.9% had subclinical hypothyroidism. TSH level was significantly associated with higher BP (P
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.248310