The need for adaptability in detection, characterization, and attribution of biosecurity threats

Modern biotechnology necessitates robust biosecurity protocols to address the risk of engineered biological threats. Current efforts focus on screening DNA and rejecting the synthesis of dangerous elements but face technical and logistical barriers. Screening should integrate into a broader strategy...

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Bibliographic Details
Published in:Nature communications 2024-12, Vol.15 (1), p.10699-9
Main Authors: Mo, William, Vaiana, Christopher A., Myers, Chris J.
Format: Article
Language:English
Subjects:
631/553/552
631/61
Adaptability
Biosecurity
Biotechnology
Bioterrorism - prevention & control
Deoxyribonucleic acid
Developmental stages
DNA
DNA - analysis
DNA - genetics
DNA biosynthesis
Humanities and Social Sciences
Humans
multidisciplinary
Perspective
Robustness
Science
Science (multidisciplinary)
Screening
Security Measures
Threat evaluation
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Summary:Modern biotechnology necessitates robust biosecurity protocols to address the risk of engineered biological threats. Current efforts focus on screening DNA and rejecting the synthesis of dangerous elements but face technical and logistical barriers. Screening should integrate into a broader strategy that addresses threats at multiple stages of development and deployment. The success of this approach hinges upon reliable detection, characterization, and attribution of engineered DNA. Recent advances notably aid the potential to both develop threats and analyze them. However, further work is needed to translate developments into biosecurity applications. This work reviews cutting-edge methods for DNA analysis and recommends avenues to improve biosecurity in an adaptable manner. Modern biotechnology necessitates robust biosecurity protocols to address the risk of engineered biological threats. In this Perspective, the authors review cutting-edge methods for DNA analysis and recommend avenues to improve biosecurity in an adaptable manner.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-55436-y