New Insights into the Occurrence of Matrix Metalloproteases -2 and -9 in a Cohort of Breast Cancer Patients and Proteomic Correlations

Matrix metalloproteases (MMPs) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix (ECM). Within the 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9 have been regarded as pri...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2018-07, Vol.7 (8), p.89
Main Authors: Di Cara, Gianluca, Marabeti, Maria Rita, Musso, Rosa, Riili, Ignazio, Cancemi, Patrizia, Pucci Minafra, Ida
Format: Article
Language:English
Subjects:
Breast cancer
Cancer therapies
Carcinoma
Enzymes
Extracellular matrix
Gelatinase A
Gelatinase B
matrix metalloproteases
Medical prognosis
Medical research
Metastasis
Mortality
Proteins
proteomics
Tumorigenesis
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Summary:Matrix metalloproteases (MMPs) are a family of well-known enzymes which operate prevalently in the extracellular domain, where they fulfil the function of remodeling the extracellular matrix (ECM). Within the 26 family members, encoded by 24 genes in humans, MMP-2 and MMP-9 have been regarded as primarily responsible for the basement membrane and peri-cellular ECM rearrangement. In cases of infiltrating carcinomas, which arise from the epithelial tissues of a gland or of an internal organ, a marked alteration of the expression and the activity levels of both MMPs is known to occur. The present investigation represents the continuation and upgrading of our previous studies, now focusing on the occurrence and intensity levels of MMP-2 and -9 and their proteomic correlations in a cohort of 80 breast cancer surgical tissues.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells7080089