Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates d...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2023-02, Vol.19 (1), p.212-216
Main Authors: Lerch, Swantje, Fritsch, Stefan, Strassner, Thomas
Format: Article
Language:English
Subjects:
Acids
Acylation
Benzene
Catalysis
Catalysts
Chemistry
Chloride
Ferric chloride
friedel–crafts acylation
Full Research Paper
homogeneous catalysis
Hydrocarbons
ionic liquids
iron catalysis
taails
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Summary:An iron(III) chloride hexahydrate-catalyzed Friedel-Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.19.20