Biofilm matrix and its regulation in Pseudomonas aeruginosa

Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render bio...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Molecular Sciences 2013-10, Vol.14 (10), p.20983-21005
Main Authors: Wei, Qing, Ma, Luyan Z
Format: Article
Language:English
Subjects:
Animals
anti-biofilm
biofilm matrix
Biofilms - growth & development
exopolysaccharides
gene regulation
Pseudomonas aeruginosa
Pseudomonas aeruginosa - growth & development
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render biofilm a source of chronic and persistent infections. A deeper understanding of biofilms will ultimately provide insights into the development of alternative treatment for biofilm infections. The opportunistic pathogen Pseudomonas aeruginosa, a model bacterium for biofilm research, is notorious for its ability to cause chronic infections by its high level of drug resistance involving the formation of biofilms. In this review, we summarize recent advances in biofilm formation, focusing on the biofilm matrix and its regulation in P. aeruginosa, aiming to provide resources for the understanding and control of bacterial biofilms.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms141020983