NLRP3 Inflammasome and MS/EAE

Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of...

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Published in:Autoimmune Diseases 2013-01, Vol.2013 (2013), p.256-263
Main Authors: Inoue, Makoto, Shinohara, Mari L.
Format: Article
Language:English
Subjects:
Adapter proteins
Animal models
Apoptosis
Cytokines
Experimental allergic encephalomyelitis
Immune system
Inflammasomes
Innate immunity
Lymphocytes
Multiple sclerosis
Mutation
Pathogens
Potassium
Review
Spinal cord
Uric acid
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description Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development.
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source Wiley Online Library Open Access; Publicly Available Content Database; PubMed Central
subjects Adapter proteins
Animal models
Apoptosis
Cytokines
Experimental allergic encephalomyelitis
Immune system
Inflammasomes
Innate immunity
Lymphocytes
Multiple sclerosis
Mutation
Pathogens
Potassium
Review
Spinal cord
Uric acid
title NLRP3 Inflammasome and MS/EAE
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