Coombs-negative haemolytic anaemia in pregnancy: A case report

We present a rare case of Coombs-negative autoimmune haemolytic anaemia in a multiparous woman in secondary care. There were no known underlying medical or obstetric risk factors for haemolytic anaemia. Following extensive investigation and a therapeutic trial of oral corticosteroids, a diagnosis wa...

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Bibliographic Details
Published in:Case reports in women's health 2021-01, Vol.29, p.e00272, Article e00272
Main Authors: George, Holly, Haslett, E., Macheta, Mac
Format: Article
Language:English
Subjects:
Anaemia
Case report
Haematology
Maternal medicine
Obstetrics
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Summary:We present a rare case of Coombs-negative autoimmune haemolytic anaemia in a multiparous woman in secondary care. There were no known underlying medical or obstetric risk factors for haemolytic anaemia. Following extensive investigation and a therapeutic trial of oral corticosteroids, a diagnosis was made. Autoimmune haemolytic anaemia is potentially fatal, and prompt diagnosis with haematology input is essential to ensure maternal and fetal safety in pregnancy and the puerperium. With only a small number of cases of Coombs-negative autoimmune haemolytic anaemia reported in the literature, we present this rare case for discussion. We highlight the importance of thorough investigation of refractory anaemia in pregnancy and consider the associated challenges. •Anaemia is pregnancy is common.•Refractory anaemia should be thoroughly investigated, it can be associated with increased maternal morbidity and mortality.•Coombs negative anaemia in pregnancy is rare•We report a case report of Coombs negative anaemia in pregnancy, with no significant underlying medical or family history.
ISSN:2214-9112
2214-9112
DOI:10.1016/j.crwh.2020.e00272