Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women

Background The aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women. Methods This cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of pe...

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Published in:Journal of cachexia, sarcopenia and muscle sarcopenia and muscle, 2018-12, Vol.9 (6), p.1034-1041
Main Authors: Yoo, Jun‐Il, Kim, Mi‐Ji, Na, Jae‐Bum, Chun, Yun‐Hong, Park, Young‐Jin, Park, Yongwhi, Hah, Young‐Sool, Ha, Yong‐Chan, Park, Ki Soo
Format: Article
Language:English
Subjects:
Age
Age Factors
Aged
Aged, 80 and over
Arthritis
Body Composition
Body mass index
Cross-Sectional Studies
Diabetes
EndoPAT
Endothelial function
Endothelium - physiology
Endothelium - physiopathology
Female
Gait
Geriatric Assessment
Hand Strength
Heart failure
Hemoglobin
Humans
Laboratories
Mortality
Muscle Strength
Muscle, Skeletal - physiopathology
Musculoskeletal system
Older people
Original
Osteoporosis
Public Health Surveillance
Sarcopenia
Studies
Womens health
Working groups
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Summary:Background The aim of this study is to determine whether there is correlation between endothelial function and skeletal muscle function measured by hand grip strength in elderly women. Methods This cross‐sectional study used data of NAMGARAM‐2 cohort. The NAMGARAM‐2 cohort consisted of a group of people living in three rural communities. They were enrolled for studies on activity limitation due to age‐related musculoskeletal disorders including knee osteoarthritis, osteoporosis, and sarcopenia. They were residents aged 40 years or older. They agreed to participate in this cohort from March 2016 to May 2017. Peripheral endothelial function was assessed by reactive hyperaemia‐peripheral arterial tonometry using EndoPAT2000 system. Hand grip strength was measured using a digital hand dynamometer. Results Endothelial function index assessed by EndoPAT was worse in the low grip strength group than that in the normal group of elderly women (1.54 ± 0.51 in the low grip strength group vs. 1.77 ± 0.67 in the normal group, P = 0.003). There was a positive correlation between hand grip strength and endothelial function (r = 0.176, P = 0.007). On stepwise multivariate analysis, endothelial dysfunction (reactive hyperaemia‐peripheral arterial tonometry index 
ISSN:2190-5991
2190-6009
DOI:10.1002/jcsm.12340