The potential of polygenic scores to improve cost and efficiency of clinical trials

Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’)....

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Bibliographic Details
Published in:Nature communications 2022-05, Vol.13 (1), p.2922-4, Article 2922
Main Authors: Fahed, Akl C., Philippakis, Anthony A., Khera, Amit V.
Format: Article
Language:English
Subjects:
631/208/212/2166
692/308/2779/777
692/53/2422
692/53/2423
Clinical trials
Clinical Trials as Topic - economics
Comment
Costs and Cost Analysis
Deoxyribonucleic acid
DNA
Enrichment
Health risks
Humanities and Social Sciences
Humans
multidisciplinary
Multifactorial Inheritance - genetics
Risk assessment
Science
Science (multidisciplinary)
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Description
Summary:Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’).
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-30675-z