Sensory Circuit Remodeling and Movement Recovery After Spinal Cord Injury

Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticoco...

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Bibliographic Details
Published in:Frontiers in neuroscience 2021-12, Vol.15, p.787690-787690
Main Authors: Moreno-López, Yunuen, Hollis, Edmund R
Format: Article
Language:English
Subjects:
corticocortical
corticospinal
movement recovery
Neuroscience
rehabilitation
spinal cord injury
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Summary:Restoring sensory circuit function after spinal cord injury (SCI) is essential for recovery of movement, yet current interventions predominantly target motor pathways. Integrated cortical sensorimotor networks, disrupted by SCI, are critical for perceiving, shaping, and executing movement. Corticocortical connections between primary sensory (S1) and motor (M1) cortices are critical loci of functional plasticity in response to learning and injury. Following SCI, in the motor cortex, corticocortical circuits undergo dynamic remodeling; however, it remains unknown how rehabilitation shapes the plasticity of S1-M1 networks or how these changes may impact recovery of movement.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2021.787690