One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density

Recent studies have shown that probiotic supplementation has beneficial effects on bone metabolism. In a randomized controlled trial (RCT) we demonstrated that supplementation of Lactobacillus reuteri ATCC PTA 6475 reduced bone loss in older women with low bone mineral density. To investigate the me...

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Bibliographic Details
Published in:NPJ biofilms and microbiomes 2022-10, Vol.8 (1), p.84-84, Article 84
Main Authors: Li, Peishun, Ji, Boyang, Luo, Hao, Sundh, Daniel, Lorentzon, Mattias, Nielsen, Jens
Format: Article
Language:English
Subjects:
631/326/2565/2134
692/698/2741/2135
akkermansia-muciniphila
Biofilms
Biomedical and Life Sciences
Biotechnology & Applied Microbiology
Bone density
Bone loss
Bone mineral density
Bone turnover
Dietary supplements
genome
Inflammation
Intestinal microflora
Lactobacillus reuteri
Life Sciences
Medical Microbiology
Metabolism
Microbial Ecology
Microbial Genetics and Genomics
Microbiology
Microbiology in the medical area
Microbiomes
Microbiota
Mikrobiologi inom det medicinska området
Probiotics
Supplements
Tibia
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Summary:Recent studies have shown that probiotic supplementation has beneficial effects on bone metabolism. In a randomized controlled trial (RCT) we demonstrated that supplementation of Lactobacillus reuteri ATCC PTA 6475 reduced bone loss in older women with low bone mineral density. To investigate the mechanisms underlying the effect of L. reuteri ATCC PTA 6475 on bone metabolism, 20 women with the highest changes (good responders) and the lowest changes (poor responders) in tibia total volumetric BMD after one-year supplementation were selected from our previous RCT. In the current study we characterized the gut microbiome composition and function as well as serum metabolome in good responders and poor responders to the probiotic treatment as a secondary analysis. Although there were no significant differences in the microbial composition at high taxonomic levels, gene richness of the gut microbiota was significantly higher ( P  
ISSN:2055-5008
2055-5008
DOI:10.1038/s41522-022-00348-2