A Comparative Analysis of Strain and 2D Shear Wave Elastography in the Diagnosis of Autoimmune Thyroiditis in Pediatric Patients

This paper aims to assess the usefulness of shear-wave elastography (SWE) and strain elastography (SE) for identifying and monitoring thyroid gland changes in children diagnosed with chronic autoimmune thyroiditis (CAT). Our study included 77 children between the ages of six and eighteen. Of these,...

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Bibliographic Details
Published in:Biomedicines 2023-07, Vol.11 (7), p.1970
Main Authors: Roi, Cristina Mihaela, Borlea, Andreea, Mihuta, Monica Simina, Paul, Corina, Stoian, Dana
Format: Article
Language:English
Subjects:
Autoimmune diseases
Children
Comparative analysis
Deformation
Electronics industry
Graves disease
Hashimoto
Health aspects
Hormone replacement therapy
Hypothyroidism
Pathology
Pediatrics
shear-wave elastography
strain elastography
Thyroid
Thyroid diseases
Thyroid gland
thyroid stiffness
Thyroiditis
Thyroiditis, Autoimmune
Ultrasonic imaging
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Summary:This paper aims to assess the usefulness of shear-wave elastography (SWE) and strain elastography (SE) for identifying and monitoring thyroid gland changes in children diagnosed with chronic autoimmune thyroiditis (CAT). Our study included 77 children between the ages of six and eighteen. Of these, 45 were diagnosed with CAT, while 32 had no thyroid pathology. Following a clinical examination and laboratory tests, an ultrasound was carried out, and then a SE (using a Hitachi Preirus machine) and SWE (using an Aixplorer Mach 30, Supersonic imagine, France) were performed in the same session. The median thyroid elastic index (EI) in the CAT group was 13.8 (13.3-17) kPa compared to 10.1 (9.3-11.2) kPa in healthy children ( < 0.0001). We found a median strain ratio (SR) of 1.2 (1.2-1.3) for CAT compared to 0.7 (0.6-0.9) for healthy thyroid tissue ( < 0.0001). The optimal cut-off value for predicting the presence of CAT in children using SR was >1 (Se = 82.2%, Sp = 87.5%, PPV = 90.2%, and NPV = 77.8%, AUROC = 0.850), while using SWE, the optimal cut-off value for predicting the presence of CAT in children was >12 kPa (Se = 88.9%, Sp = 93.7%, PPV = 95.2%, and NPV = 85.5%, AUROC = 0.943). Both techniques are useful for measuring thyroid tissue elasticity, and their diagnostic accuracy and reliability are comparable.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11071970