Anti-inflammatory and regenerative effects of MKARE® Eggshell Membrane: An in vitro osteoarthritis model and placebo-controlled clinical study

[Display omitted] •Osteoarthritis is one of the most prevalent musculoskeletal diseases, leading to a rising demand for innovative interventions to alleviate its symptoms.•Eggshell membrane (ESM) has demonstrated a promising therapeutic potential in wound healing and tissue repair due to its diverse...

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Bibliographic Details
Published in:Journal of functional foods 2024-05, Vol.116, p.106119, Article 106119
Main Authors: Casado-Santos, Alejandro, La Nuez-García, Manuel A., Álvarez-Rodríguez, Patricia, González-Cubero, Elsa, González-Rodríguez, Yaiza, Luisa González-Fernández, Maria, Villar-Suárez, Vega
Format: Article
Language:English
Subjects:
Chondrocytes
Eggshell
Eggshell membrane
Osteoarthritis
Pain
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Summary:[Display omitted] •Osteoarthritis is one of the most prevalent musculoskeletal diseases, leading to a rising demand for innovative interventions to alleviate its symptoms.•Eggshell membrane (ESM) has demonstrated a promising therapeutic potential in wound healing and tissue repair due to its diverse bioactive-rich molecular composition.•The freshness of the ESM in the moment of extraction and processing is the key to maximize the anti-inflammatory and chondroprotective properties of the final product.•MKARE® has demonstrated both via in vivo and in vitro assays that fresh ESM shows an overall better performance than its degraded counterparts. MKARE®, a 100% natural ingredient derived from fresh eggshell membrane (ESM), has a rich composition in bioactive compounds like collagen, hyaluronic acid, and elastin. These components are beneficial for managing osteoarthritis (OA) due to their anti-inflammatory and regenerative properties. Highlighting the significance of freshness, our research has shown that the effectiveness of MKARE® is higher than that of other commercial products based on ESM that have been stored for several days at room temperature, losing their bioactive compounds. This study explores the MKARE® anti-inflammatory capacity through an in vitro and clinical analyses, demonstrating its ability to alleviate OA symptoms and improve joint health. This underscores the crucial role of freshness in optimizing the therapeutic benefits.
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2024.106119