Five New Meroterpenoids from the Fruiting Bodies of the Basidiomycete Clitocybe clavipes with Cytotoxic Activity

Five new meroterpenoids, clavipols A-B ( - ) with a 12-membered ether ring and clavilactones G-I ( - ) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete . Their structures were determined by c...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-11, Vol.24 (22), p.4015
Main Authors: Zhaocui, Sun, Xudong, Xu, Hanqiao, Liang, Xinyi, Xia, Guoxu, Ma, Leiling, Shi
Format: Article
Language:English
Subjects:
Absolute configuration
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
basidiomycete
Basidiomycota - chemistry
Carbon
Cell Line, Tumor
Circular dichroism
clitocybe clavipes
Cytotoxicity
Dichroism
Fruit bodies
Fruiting Bodies, Fungal - chemistry
Humans
Hydroquinone
meroterpenoids
Metabolites
Models, Molecular
Molecular Structure
Spectrum analysis
Terpenes - chemistry
Terpenes - pharmacology
Tumor cell lines
Tumors
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Summary:Five new meroterpenoids, clavipols A-B ( - ) with a 12-membered ether ring and clavilactones G-I ( - ) having a 10-membered carbocycle connected to a hydroquinone and an α,β-epoxy/unsaturated lactone, were obtained from the fruiting bodies of the basidiomycete . Their structures were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of was established by quantum chemical calculations of electronic circular dichroism (ECD). All the isolated compounds ( - ) were tested for their cytotoxic activity against three human tumor cell lines (Hela, SGC-7901, and SHG-44) in vitro after treatment for 48 h. Compound exhibited moderate cytotoxic activity against Hela and SGC-7901 tumor cell lines, with IC values of 23.5 and 14.5 µM, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24224015