Metal-Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal-organic framework-based chemo-photothermal combinational system was co...

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Bibliographic Details
Published in:Pharmaceutics 2019-09, Vol.11 (9), p.463
Main Authors: Wu, Biyuan, Fu, Jintao, Zhou, Yixian, Wang, Jing, Feng, Xiaoqian, Zhao, Yiting, Zhou, Guiling, Lu, Chao, Quan, Guilan, Pan, Xin, Wu, Chuanbin
Format: Article
Language:English
Subjects:
Ablation
anti-bacteria
Antibiotics
Bacteria
Bacterial infections
chemo-photothermal combination therapy
Cytotoxicity
Drug resistance
Heat resistance
Hyperthermia
indocyanine green
Lasers
metal–organic frameworks
Morphology
Nanoparticles
Pathogens
Porous materials
Scanning electron microscopy
Staphylococcus infections
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Summary:Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal-organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics11090463