Cellular reprogramming as a tool to model human aging in a dish

The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent ste...

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Bibliographic Details
Published in:Nature communications 2024-02, Vol.15 (1), p.1816-1816, Article 1816
Main Authors: Pitrez, Patricia R., Monteiro, Luis M., Borgogno, Oliver, Nissan, Xavier, Mertens, Jerome, Ferreira, Lino
Format: Article
Language:English
Subjects:
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Age
Age related diseases
Aged
Aging
Animal models
Cancer
Cardiovascular disease
Cell culture
Cellular Reprogramming - genetics
DNA methylation
Epigenetics
Humanities and Social Sciences
Humans
Immune system
Induced Pluripotent Stem Cells
Life span
Longevity
multidisciplinary
Mutation
Perspective
Physiology
Pluripotency
Proteins
Risk factors
Science
Science (multidisciplinary)
Senescence
Stem cells
Three dimensional models
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Summary:The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions. The development of human cellular models of aging that surpass the limitations of animal models of aging is urgent. Here, the authors explore the opportunities and limitations of cellular reprogramming to create reliable aging in vitro models and their potential for the discovery of anti-aging compounds.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-024-46004-5