Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database

The association between perioperative blood transfusion and the prognosis of patients with gastric cancer is still unclear. A total of 1581 patients with gastric cancer who underwent curative gastrectomy from 2000 to 2008 were evaluated. Perioperative blood transfusion was defined as the transfusion...

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Published in:BMC cancer 2018-06, Vol.18 (1), p.649-649, Article 649
Main Authors: Liu, Xiaowen, Ma, Mingze, Huang, Hua, Wang, Yanong
Format: Article
Language:English
Subjects:
Adenocarcinoma - mortality
Adenocarcinoma - surgery
Adult
Age
Aged
Anemia
Blood
Blood transfusion
Blood transfusions
Breast cancer
Care and treatment
Databases, Factual
Erythrocyte Transfusion - adverse effects
Erythrocytes
Female
Females
Gastrectomy
Gastric cancer
Health aspects
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Patient outcomes
Patients
Perioperative blood transfusion
Perioperative Care - adverse effects
Perioperative Care - methods
Prognosis
Proportional Hazards Models
Retrospective Studies
Statistical analysis
Stomach cancer
Stomach Neoplasms - mortality
Stomach Neoplasms - surgery
Studies
Surgery
Survival analysis
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Wang, Yanong
description The association between perioperative blood transfusion and the prognosis of patients with gastric cancer is still unclear. A total of 1581 patients with gastric cancer who underwent curative gastrectomy from 2000 to 2008 were evaluated. Perioperative blood transfusion was defined as the transfusion of packed red blood cells within seven days before surgery, during surgery, or within the postoperative hospitalization period. The association between perioperative blood transfusion and prognosis was evaluated using univariate and multivariate Cox regression analyses. Of 1581 patients, 298 patients (19%) received perioperative blood transfusion. Perioperative blood transfusion correlated with older age (P 
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A total of 1581 patients with gastric cancer who underwent curative gastrectomy from 2000 to 2008 were evaluated. Perioperative blood transfusion was defined as the transfusion of packed red blood cells within seven days before surgery, during surgery, or within the postoperative hospitalization period. The association between perioperative blood transfusion and prognosis was evaluated using univariate and multivariate Cox regression analyses. Of 1581 patients, 298 patients (19%) received perioperative blood transfusion. Perioperative blood transfusion correlated with older age (P &lt; 0.001); larger tumor size (P &lt; 0.001); and more advanced stage (P &lt; 0.001). Five-year survival rate was 40% in patients who had perioperative blood transfusion and 55% patients who did not have perioperative blood transfusion, and the difference was statistically significant (P &lt; 0.001). Multivariate analysis showed that perioperative blood transfusion was defined as independent prognostic factor. Perioperative blood transfusion was associated with worse outcomes in patients with stage III (P &lt; 0.001). Perioperative blood transfusion independently correlated with poorer prognosis in patients with gastric cancer.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/s12885-018-4574-4</identifier><identifier>PMID: 29890957</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Adult ; Age ; Aged ; Anemia ; Blood ; Blood transfusion ; Blood transfusions ; Breast cancer ; Care and treatment ; Databases, Factual ; Erythrocyte Transfusion - adverse effects ; Erythrocytes ; Female ; Females ; Gastrectomy ; Gastric cancer ; Health aspects ; Humans ; Kaplan-Meier Estimate ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Multivariate analysis ; Patient outcomes ; Patients ; Perioperative blood transfusion ; Perioperative Care - adverse effects ; Perioperative Care - methods ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Statistical analysis ; Stomach cancer ; Stomach Neoplasms - mortality ; Stomach Neoplasms - surgery ; Studies ; Surgery ; Survival analysis</subject><ispartof>BMC cancer, 2018-06, Vol.18 (1), p.649-649, Article 649</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. 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Multivariate analysis showed that perioperative blood transfusion was defined as independent prognostic factor. Perioperative blood transfusion was associated with worse outcomes in patients with stage III (P &lt; 0.001). Perioperative blood transfusion independently correlated with poorer prognosis in patients with gastric cancer.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>29890957</pmid><doi>10.1186/s12885-018-4574-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Adenocarcinoma - mortality
Adenocarcinoma - surgery
Adult
Age
Aged
Anemia
Blood
Blood transfusion
Blood transfusions
Breast cancer
Care and treatment
Databases, Factual
Erythrocyte Transfusion - adverse effects
Erythrocytes
Female
Females
Gastrectomy
Gastric cancer
Health aspects
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Patient outcomes
Patients
Perioperative blood transfusion
Perioperative Care - adverse effects
Perioperative Care - methods
Prognosis
Proportional Hazards Models
Retrospective Studies
Statistical analysis
Stomach cancer
Stomach Neoplasms - mortality
Stomach Neoplasms - surgery
Studies
Surgery
Survival analysis
title Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database
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