High efficacy of microbial larvicides for malaria vectors control in the city of Yaounde Cameroon following a cluster randomized trial

The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measures could...

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Published in:Scientific reports 2021-08, Vol.11 (1), p.1-15, Article 17101
Main Authors: Antonio-Nkondjio, Christophe, Doumbe-Belisse, P., Djamouko-Djonkam, L., Ngadjeu, C. S., Talipouo, A., Kopya, E., Bamou, R., Mayi, M. P. Audrey, Sonhafouo-Chiana, N., Nkahe, D. L., Tabue, R., Fosah, D. Achu, Bigoga, Jude D., Awono-Ambene, P., Wondji, Charles S.
Format: Article
Language:English
Subjects:
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Biting
Breeding
Data collection
Disease transmission
Humanities and Social Sciences
Inoculation
Insecticides
Integrated control
Larvae
Larvicides
Light traps
Malaria
multidisciplinary
Pesticide resistance
Science
Science (multidisciplinary)
Urban areas
Urban environments
Vector-borne diseases
Vectors
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Summary:The rapid expansion of insecticide resistance and outdoor malaria transmission are affecting the efficacy of current malaria control measures. In urban settings, where malaria transmission is focal and breeding habitats are few, fixed and findable, the addition of anti-larval control measures could be efficient for malaria vector control. But field evidences for this approach remains scarce. Here we provide findings of a randomized-control larviciding trial conducted in the city of Yaoundé that support the efficacy of this approach. A two arms random control trial design including 26 clusters of 2 to 4 km 2 each (13 clusters in the intervention area and 13 in the non-intervention area) was used to assess larviciding efficacy. The microbial larvicide VectoMax combining Bacillus thuringiensis var israelensis (Bti) and Bacillus sphaericus in a single granule was applied every 2 weeks in all standing water collection points. The anopheline density collected using CDC light traps was used as the primary outcome, secondary outcomes included the entomological inoculation rate, breeding habitats with anopheline larvae, and larval density. Baseline entomological data collection was conducted for 17 months from March 2017 to July 2018 and the intervention lasted 26 months from September 2018 to November 2020. The intervention was associated with a reduction of 68% of adult anopheline biting density and of 79% of the entomological inoculation rate (OR 0.21; 95% CI 0.14–0.30, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96362-z