Short telomere length and its correlation with gene mutations in myelodysplastic syndrome

Telomere erosion can lead to genomic instability and cancer progression. It has been suggested that the shortest telomere, not the average telomere length (TL), is critical for cell viability. Some studies have shown shorter TL in myelodysplastic syndrome (MDS) patients but the critically short telo...

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Bibliographic Details
Published in:Journal of hematology and oncology 2016-07, Vol.9 (1), p.62-62, Article 62
Main Authors: Hwang, Sang Mee, Kim, Seon Young, Kim, Jung Ah, Park, Hee-Sue, Park, Si Nae, Im, Kyongok, Kim, Kwantae, Kim, Sung-Min, Lee, Dong Soon
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Analysis
Bone marrow
Bone Marrow Cells
Chromosome Aberrations
Chromosomes
Development and progression
DNA methylation
Female
Gene mutations
Genes
Genetic aspects
Genomic Instability
Hematology
Humans
Hybridization
In Situ Hybridization, Fluorescence
Influence
Male
Middle Aged
Mutation
Myelodysplastic syndromes
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Oncology
Patients
Quantitative fluorescence in situ hybridization
Single cell
Survival Rate
Telomerase
Telomere - pathology
Telomere length
Telomere Shortening
Telomeres
Yeast
Young Adult
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Summary:Telomere erosion can lead to genomic instability and cancer progression. It has been suggested that the shortest telomere, not the average telomere length (TL), is critical for cell viability. Some studies have shown shorter TL in myelodysplastic syndrome (MDS) patients but the critically short telomeres, the variability of TL within individual patient has not been evaluated. Thus, we aimed to investigate the TL of MDS patients and assessed the association of TL with recurrent genetic mutations in MDS. We measured the TL of bone marrow nucleated cells for diagnostic samples at a single-cell level by quantitative fluorescence in situ hybridization (Q-FISH) for 58 MDS patients and analyzed the minimum, median, average, standard deviation, average of the 0th to 10th percentile TL within a patient, and the proportion of cells with TL that is shorter than the lowest 10th percentile of the normal control (NC). The correlations of TL to clinical parameters, cytogenetic results, and genetic mutations were assessed. MDS patients showed eroded telomeres and narrow distribution compared to the NC (P 
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-016-0287-9