Retrospective meta-transcriptomic identification of severe dengue in a traveller returning from Africa to Sweden, 1990

Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-se...

Full description

Saved in:
Bibliographic Details
Published in:One health 2021-06, Vol.12, p.100217, Article 100217
Main Authors: Alfsnes, Kristian, Lagerqvist, Nina, Vene, Sirkka, Bohlin, Jon, Verner-Carlsson, Jenny, Ekqvist, David, Bråve, Andreas, Holmes, Edward C., Shi, Weifeng, Pettersson, John H.-O.
Format: Article
Language:English
Subjects:
Dengue haemorrhagic fever
Dengue virus
Human pegivirus
Meta-transcriptomics
Research Paper
RNA-sequencing
Viral haemorrhagic fever
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pathogens associated with haemorrhagic fever commonly have zoonotic origins. The first documented imported case of likely viral severe haemorrhagic fever in Sweden occurred in 1990. Despite extensive study, no aetiological agent was identified. Following retrospective investigation with total RNA-sequencing of samples collected between 7 and 36 days from onset of symptoms we identified dengue virus 3 (DENV-3) and a human pegivirus (HPgV). We conclude that the patient likely suffered from haemorrhagic symptoms due to an atypical severe and undiagnosed dengue infection.
ISSN:2352-7714
2352-7714
DOI:10.1016/j.onehlt.2021.100217