In vivo demonstration of a novel non-invasive model for inducing localized hypothermia to ameliorate hepatotoxicity

Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propose the use...

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Bibliographic Details
Published in:Scientific reports 2021-09, Vol.11 (1), p.18620-18620, Article 18620
Main Authors: Tan, Yeong Lan, Nga, Min En, Ho, Han Kiat
Format: Article
Language:English
Subjects:
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Acetaminophen
Body temperature
Cooling
Feasibility studies
Hepatotoxicity
Histology
Humanities and Social Sciences
Hypothermia
Liver
multidisciplinary
Science
Science (multidisciplinary)
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Summary:Moderate hypothermia (32 °C) has been previously shown to ameliorate drug-induced liver injuries in vitro. However, there are concerns regarding its clinical relevance as it remains a challenge to perform selective liver cooling in a non-invasive manner. To reconcile this dilemma, we propose the use of pulsed cooling for regional hypothermic conditioning in liver. This involves intermittent cooling applied in pulses of 15 min each, with a one-hour recovery interval between pulses. Cooling is achieved by applying ice packs to the cutaneous region overlying the liver. Through an in vivo C57BL/6NTac mouse study, we demonstrated the feasibility of attaining localized hypothermia close to the liver while maintaining core body temperature. This has successfully ameliorated acetaminophen-induced liver injury based on the liver function tests, liver histology and total weight change. Collectively, we provide a proof of concept for pulsed external localized cooling as being clinically actionable to perform induced selective hypothermia.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-98078-6