Drug resistance in pulmonary tuberculosis in new and previously treated cases: Experience from Turkey

Summary The emergence of drug resistance is a major problem for tuberculosis (TB) control. The aim of this study was to determine the rates of resistance against TB drugs in patients with pulmonary tuberculosis (PTB). Data from 387 patients with active PTB between the years of 1999 and 2004 from the...

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Bibliographic Details
Published in:Journal of infection and public health 2013-08, Vol.6 (4), p.276-282
Main Authors: Komurcuoglu, Berna, Senol, Gunes, Balci, Gunseli, Yalnız, Enver, Ozden, Emel
Format: Article
Language:English
Subjects:
Adult
Antitubercular Agents - pharmacology
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
Drug resistance
Drug Resistance, Bacterial
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Male
Medical sciences
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - isolation & purification
Prevalence
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis control programs
Tuberculosis, Multidrug-Resistant - epidemiology
Tuberculosis, Multidrug-Resistant - microbiology
Tuberculosis, Pulmonary - epidemiology
Tuberculosis, Pulmonary - microbiology
Turkey - epidemiology
Young Adult
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Summary:Summary The emergence of drug resistance is a major problem for tuberculosis (TB) control. The aim of this study was to determine the rates of resistance against TB drugs in patients with pulmonary tuberculosis (PTB). Data from 387 patients with active PTB between the years of 1999 and 2004 from the Research and Education Hospital for Chest Diseases and Chest Surgery were evaluated retrospectively. The patients were categorized as new, re-treatment, extrapulmonary and chronic cases. The study group consisted of 268 (69%) new, 57 (14.7%) re-treatment, 49 (12.6%) extrapulmonary and 13 (3.3%) chronic TB cases. The rates of resistance to isoniazid (INH), rifampicin (R), ethambutol (E) and streptomycin (S) were calculated separately for each group. The resistance to any of the drugs was 7.8% in the new cases, 58.5% in the re-treatment cases and 100% in the chronic cases. The multidrug-resistance (MDR)-TB rates were found to be 2.16%, 11.3% and 92.3% among the new, re-treatment and chronic cases, respectively. These data are important as they reflect the drug resistance rates during the pre-notification time period in western Turkey.
ISSN:1876-0341
1876-035X
DOI:10.1016/j.jiph.2013.02.005