P126 Association between health-related quality of life and physical activity in systemic lupus erythematosus patients from two centres in Portugal

• Published in: Lupus science & medicine 2024-03, Vol.11 (Suppl 1), p.A130-A131
• Main Authors: Koning, Koen F de, Oliveira, Daniel G, Oliveira, Natália, Andrade, Elva B, Costa, Paulo P, Vasconcelos, Carlos
• Format: Article
• Language: English
• Subjects: Body image; Exercise; Lupus; Physical fitness; Poster Presentations; Quality of life; Self image
• ISSN: 2053-8790
• DOI: 10.1136/lupus-2024-el.180

ObjectiveSystemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that impacts health-related quality of life (HRQoL). Exercise is a potential determinant of HRQoL. We characterize HRQoL and exercise habits of SLE patients from two centres in Portugal.MethodsHRQoL was evaluated through the SLE-specific LupusQoL-PT (higher is better). Exercise habits were standardized using the International Physical Activity Questionnaire translated into Portuguese. 4 patients recruited in flare were reassessed at 1 year, in remission; these scores were considered independently (total 24 LupusQoL-PT, 22 IPAQ responses).ResultsTwenty SLE patients (18 female; median age 38,3 years, median disease duration 12,6 years) were recruited. Median SLEDAI score was 6,0 (IQR 4,7–10), with 55% patients recruited in flare and 15% had at least some organ damage (SDI ≥ 1). Most (70%) took hydroxychloroquine (table 1). Median LupusQoL-PT scores were lowest for fatigue (62,5) and highest for intimate relationship domains (93,8) (table 2). Lower disease activity (SLEDAI 1h/week improved emotional (83,3 vs 54,2, p=0,048) and tended to improve burden to others scoring (table 2). Sitting time was generally high (mean 40,9± 22,5 hours/week) and not associated with any HRQoL domain.ConclusionFatigue is the lowest scoring domain in this cohort. Higher disease activity impacts burden to others and body image HRQoL. Portuguese SLE patients have very low rates of physical activity. Patients with greater exercise habits score higher on all LupusQoL domains. Even one hour per week of activity is associated with improvement in HRQoL. This underscores the importance of addressing physical activity in SLE management and research.AcknowledgementsLindora Pires, Director, Internal Medicine Department, CHTS. Fátima Farinha, Director, UIC, CHUdSA. Fundação para Ciência e Tecnologia. UIDB/00215/2020; UIDP/00215/2020Abstract P126 Table 1Systemic lupus erythematosus (SLE) patient demographic and clinical characte