Selection of bioactive chemical markers for anti-aging skin assessment of Dimocarpus longan Lour. leaf extract

[Display omitted] Hydroethanolic longan (Dimocarpus longan Lour.) leaf extract has reported remarkable biological activities related to the aging process for use in cosmeceuticals. Finding the bioactive chemical marker (BCM) could play a crucial role for cosmeceutical manufacturers in guaranteeing t...

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Bibliographic Details
Published in:Arabian journal of chemistry 2023-08, Vol.16 (8), p.104954, Article 104954
Main Authors: Doungsaard, Pimjai, Chansakaow, Sunee, Poomanee, Worrapan, Sirithunyalug, Busaban, Chaichit, Siripat, Leelapornpisid, Pimporn
Format: Article
Language:English
Subjects:
Anti-aging
Bioactive chemical markers
Dimocarpus longan
HPLC fingerprint
Molecular docking
Phytochemistry
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Summary:[Display omitted] Hydroethanolic longan (Dimocarpus longan Lour.) leaf extract has reported remarkable biological activities related to the aging process for use in cosmeceuticals. Finding the bioactive chemical marker (BCM) could play a crucial role for cosmeceutical manufacturers in guaranteeing the quality of the extract and its efficacy. This study aimed to select the most potential BCM established and predicted for the anti-aging skin of hydroethanolic longan leaf extract. The assessment of anti-aging of the skin was determined by evaluating in vitro antioxidant activities, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and inhibiting lipid peroxidation assay. Furthermore, anti-hyaluronidase and anti-collagenase activity were also determined. The extract underwent bioassay-guided fractionation using normal phase preparative-thin layer chromatography. Ethyl gallate in the fractionated extract possessed biological activities as a high proportion part. The strong positive linear relationship between DPPH scavenging, lipid peroxidation inhibition, anti-collagenase, and anti-hyaluronidase activity (r = 0.997, 0.972, 0.998, and 0.998, respectively) under the deterioration of the ethyl gallate was shown. The molecular docking of ethyl gallate to collagenase and hyaluronidase resulted in a good and acceptable binding affinity. Therefore, ethyl gallate could be potentially used as a bioactive chemical marker for hydroethanolic longan leaf extract in pharmaceutical and cosmeceutical applications.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2023.104954