Adiponectin‐expressing Treg‐containing T cell fraction inhibits tumor growth in orthotopically implanted triple‐negative breast cancer

BackgroundIn our previous study, we identified a population of adiponectin expressing regulatory T cells (Tregs) residing within thymic nurse cell complexes, which were capable of inhibiting the development of breast cancer in vitro. Triple-negative breast cancer (TNBC) with no proper treatment at p...

Full description

Saved in:
Bibliographic Details
Published in:Thoracic cancer 2023-10, Vol.14 (30), p.3058-3062
Main Authors: Chikaishi, Wakana, Higashi, Toshiya, Hayashi, Hirokatsu, Hanamatsu, Yuki, Futamura, Manabu, Matsuhashi, Nobuhisa, Saigo, Chiemi, Takeuchi, Tamotsu
Format: Article
Language:English
Subjects:
adiponectin
adoptive cell therapy
Antibodies
A‐TregTF
Breast cancer
Cancer therapies
Cell death
cell‐in‐cell
Cloning
Cytotoxicity
Lymphocytes
Metastasis
Original
Student's t-test
triple‐negative breast cancer
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BackgroundIn our previous study, we identified a population of adiponectin expressing regulatory T cells (Tregs) residing within thymic nurse cell complexes, which were capable of inhibiting the development of breast cancer in vitro. Triple-negative breast cancer (TNBC) with no proper treatment at present is characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2. In this study, we aimed to investigate the potential of a cultured T cell fraction comprising adiponectin-expressing Tregs, referred to as A-TregTF (adiponectin-expressing Treg-containing T cell fraction), in inhibiting the progression of TNBC in vivo.MethodsThe efficacy of a spontaneously expanding T cell fraction comprising adiponectin-expressing Treg in inhibiting tumor growth was analyzed in a murine orthotopic 4 T1-Luc TNBC model.ResultsThe treatment with T cell fraction containing adiponectin-expressing Tregs significantly inhibited the growth and metastasis of orthotopically transplanted 4 T1-Luc tumor cells. Histopathological examination further revealed that the adiponectin-expressing Tregs infiltrated the tumor tissue via a cell-in-cell mechanism and were found to be specifically localized around the necrotic areas.ConclusionsBased on our findings, the T cell fraction comprising adiponectin-expressing Tregs, represents a potential candidate for adoptive cell therapy against TNBC.
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.15102