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Efficacy and safety of ethanol injection for endobronchial tumor debulking (a feasibility study)
Airway obstruction by malignant tumors may lead to dyspnea, cough, hemoptysis, atelectasis and pneumonia. The aim was to assess safety and efficacy of ethanol injection in debulking of endobronchial malignant tumors. It included 20 patients with endobronchial malignant tumors and divided into 2 grou...
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Published in: | The Egyptian journal of chest diseases and tuberculosis 2017-07, Vol.66 (3), p.471-476 |
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container_end_page | 476 |
container_issue | 3 |
container_start_page | 471 |
container_title | The Egyptian journal of chest diseases and tuberculosis |
container_volume | 66 |
creator | ElBadrawy, Mohammad Khairy Moustafa, Amal Fathy Moawad, Amr Abdelhamid El-Sherbiny, Doaa Hashem Hasan Farouk, Fatma Rahman, Manar Ahmad Abdel |
description | Airway obstruction by malignant tumors may lead to dyspnea, cough, hemoptysis, atelectasis and pneumonia.
The aim was to assess safety and efficacy of ethanol injection in debulking of endobronchial malignant tumors.
It included 20 patients with endobronchial malignant tumors and divided into 2 groups randomly: group A; 10 patients subjected to ethanol injection plus chemotherapy and group B; included 10 patients treated with chemotherapy alone.
There was a significant improvement in dyspnea, cough and hemoptysis scores in group A after the end of the study (P1: 0.004, 0.014 and 0.014 respectively) and a significant improvement in group A compared with group B 2weeks after the last session of chemotherapy as regard dyspnea and cough (P2 |
doi_str_mv | 10.1016/j.ejcdt.2016.12.001 |
format | article |
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The aim was to assess safety and efficacy of ethanol injection in debulking of endobronchial malignant tumors.
It included 20 patients with endobronchial malignant tumors and divided into 2 groups randomly: group A; 10 patients subjected to ethanol injection plus chemotherapy and group B; included 10 patients treated with chemotherapy alone.
There was a significant improvement in dyspnea, cough and hemoptysis scores in group A after the end of the study (P1: 0.004, 0.014 and 0.014 respectively) and a significant improvement in group A compared with group B 2weeks after the last session of chemotherapy as regard dyspnea and cough (P2<0.001 and 0.02 respectively) but with no significant difference between both groups two weeks after the last session of chemotherapy (P2: 0.21) for hemoptysis. In group A, there was a significant improvement in Karnofsky performance scale, FEV1 and FEV1/FVC ratio at the end of the procedure (P1 0.002, 0.024 and 0.03 respectively) with a significant improvement compared with group B (P2: 0.003, 0.04 and 0.05 respectively). Two patients in group A showed improvement in CT chest with no improvement in group B. Evaluation of response with revised RECIST; in group A, one patient showed good response, 5 patients showed partial response but in group B, only 2 patients showed partial response.
Intratumoral injection of ethanol 95% is effective and safe adjuvant to chemotherapy for tumor debulking.</description><identifier>ISSN: 0422-7638</identifier><identifier>DOI: 10.1016/j.ejcdt.2016.12.001</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Ethanol ; Lung cancer ; Palliation</subject><ispartof>The Egyptian journal of chest diseases and tuberculosis, 2017-07, Vol.66 (3), p.471-476</ispartof><rights>2016 The Egyptian Society of Chest Diseases and Tuberculosis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-65e30e51ca039c23eae83da040b3542ff33084751eb545b832ef6e5e68429d253</citedby><cites>FETCH-LOGICAL-c344t-65e30e51ca039c23eae83da040b3542ff33084751eb545b832ef6e5e68429d253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S042276381630259X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids></links><search><creatorcontrib>ElBadrawy, Mohammad Khairy</creatorcontrib><creatorcontrib>Moustafa, Amal Fathy</creatorcontrib><creatorcontrib>Moawad, Amr Abdelhamid</creatorcontrib><creatorcontrib>El-Sherbiny, Doaa Hashem Hasan</creatorcontrib><creatorcontrib>Farouk, Fatma</creatorcontrib><creatorcontrib>Rahman, Manar Ahmad Abdel</creatorcontrib><title>Efficacy and safety of ethanol injection for endobronchial tumor debulking (a feasibility study)</title><title>The Egyptian journal of chest diseases and tuberculosis</title><description>Airway obstruction by malignant tumors may lead to dyspnea, cough, hemoptysis, atelectasis and pneumonia.
The aim was to assess safety and efficacy of ethanol injection in debulking of endobronchial malignant tumors.
It included 20 patients with endobronchial malignant tumors and divided into 2 groups randomly: group A; 10 patients subjected to ethanol injection plus chemotherapy and group B; included 10 patients treated with chemotherapy alone.
There was a significant improvement in dyspnea, cough and hemoptysis scores in group A after the end of the study (P1: 0.004, 0.014 and 0.014 respectively) and a significant improvement in group A compared with group B 2weeks after the last session of chemotherapy as regard dyspnea and cough (P2<0.001 and 0.02 respectively) but with no significant difference between both groups two weeks after the last session of chemotherapy (P2: 0.21) for hemoptysis. In group A, there was a significant improvement in Karnofsky performance scale, FEV1 and FEV1/FVC ratio at the end of the procedure (P1 0.002, 0.024 and 0.03 respectively) with a significant improvement compared with group B (P2: 0.003, 0.04 and 0.05 respectively). Two patients in group A showed improvement in CT chest with no improvement in group B. Evaluation of response with revised RECIST; in group A, one patient showed good response, 5 patients showed partial response but in group B, only 2 patients showed partial response.
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The aim was to assess safety and efficacy of ethanol injection in debulking of endobronchial malignant tumors.
It included 20 patients with endobronchial malignant tumors and divided into 2 groups randomly: group A; 10 patients subjected to ethanol injection plus chemotherapy and group B; included 10 patients treated with chemotherapy alone.
There was a significant improvement in dyspnea, cough and hemoptysis scores in group A after the end of the study (P1: 0.004, 0.014 and 0.014 respectively) and a significant improvement in group A compared with group B 2weeks after the last session of chemotherapy as regard dyspnea and cough (P2<0.001 and 0.02 respectively) but with no significant difference between both groups two weeks after the last session of chemotherapy (P2: 0.21) for hemoptysis. In group A, there was a significant improvement in Karnofsky performance scale, FEV1 and FEV1/FVC ratio at the end of the procedure (P1 0.002, 0.024 and 0.03 respectively) with a significant improvement compared with group B (P2: 0.003, 0.04 and 0.05 respectively). Two patients in group A showed improvement in CT chest with no improvement in group B. Evaluation of response with revised RECIST; in group A, one patient showed good response, 5 patients showed partial response but in group B, only 2 patients showed partial response.
Intratumoral injection of ethanol 95% is effective and safe adjuvant to chemotherapy for tumor debulking.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.ejcdt.2016.12.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Ethanol Lung cancer Palliation |
title | Efficacy and safety of ethanol injection for endobronchial tumor debulking (a feasibility study) |
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