Revisiting Bacterial Ubiquitin Ligase Effectors: Weapons for Host Exploitation

Protein ubiquitylation plays a central role in eukaryotic cell physiology. It is involved in several regulatory processes, ranging from protein folding or degradation, subcellular localization of proteins, vesicular trafficking and endocytosis to DNA repair, cell cycle, innate immunity, autophagy, a...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2018-11, Vol.19 (11), p.3576
Main Authors: Pisano, Antonio, Albano, Francesco, Vecchio, Eleonora, Renna, Maurizio, Scala, Giuseppe, Quinto, Ileana, Fiume, Giuseppe
Format: Article
Language:English
Subjects:
Animals
Antigens
Apoptosis
Autophagy
Bacteria
Biodegradation
Cell cycle
DNA repair
Effectors
Endocytosis
Enzymes
Humans
Immune system
Innate immunity
Kinases
Localization
Mimicry
Models, Biological
Pathogens
Phagocytosis
Physiology
Protein folding
Proteins
Review
Signal transduction
T3SS
T4SS
Tumor necrosis factor-TNF
Type III Secretion Systems - genetics
Type III Secretion Systems - metabolism
Type IV Secretion Systems - genetics
Type IV Secretion Systems - metabolism
Ubiquitin
Ubiquitin - metabolism
ubiquitin ligase
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Protein ubiquitylation plays a central role in eukaryotic cell physiology. It is involved in several regulatory processes, ranging from protein folding or degradation, subcellular localization of proteins, vesicular trafficking and endocytosis to DNA repair, cell cycle, innate immunity, autophagy, and apoptosis. As such, it is reasonable that pathogens have developed a way to exploit such a crucial system to enhance their virulence against the host. Hence, bacteria have evolved a wide range of effectors capable of mimicking the main players of the eukaryotic ubiquitin system, in particular ubiquitin ligases, by interfering with host physiology. Here, we give an overview of this topic and, in particular, we detail and discuss the mechanisms developed by pathogenic bacteria to hijack the host ubiquitination system for their own benefit.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19113576