Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Early diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC. Serum sa...

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Published in:Frontiers in endocrinology (Lausanne) 2021-11, Vol.12, p.737638-737638
Main Authors: Wang, Yichao, Zhou, Shengliang, Wang, Dun, Wei, Tao, Zhu, Jingqiang, Li, Zhihui
Format: Article
Language:English
Subjects:
Adult
biomarker
Biomarkers, Tumor - blood
complement C4-A
Complement C4a - metabolism
Endocrinology
Female
Humans
Male
Middle Aged
papillary thyroid carcinoma
plasminogen
Plasminogen - metabolism
prediction
Proteomics
Sensitivity and Specificity
Thyroid Cancer, Papillary - blood
Thyroid Cancer, Papillary - diagnosis
Thyroid Cancer, Papillary - pathology
Thyroid Neoplasms - blood
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
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container_title Frontiers in endocrinology (Lausanne)
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creator Wang, Yichao
Zhou, Shengliang
Wang, Dun
Wei, Tao
Zhu, Jingqiang
Li, Zhihui
description Early diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which could be used as a biomarker for predicting PTC. Serum samples were collected from 29 PTC patients and 29 nodular goiter (NG) patients. Five PTC serum samples and five NG serum samples were selected for proteome profiles by proteomics. Eight proteins in PTC and NG serum samples were selected for confirmation by enzyme-linked immunosorbent assay analysis. Receiver operating characteristic curves was used to evaluate the diagnostic value of potential biomarkers. Complement C4-A (C4A) and plasminogen (PLG) were significantly lower in serum samples of PTC patients compared with NG patients. C4A was observed to have excellent diagnostic accuracy for PTC, with a sensitivity of 91.67% and specificity of 83.33%. The diagnostic value of PLG for PTC was demonstrated by a sensitivity at 87.50% and specificity at 75.00%. The AUC for C4A and PLG was 0.97 ± 0.02 and 0.89 ± 0.05. C4A and PLG appeared to be excellent potential biomarkers for the prediction of PTC.
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subjects Adult
biomarker
Biomarkers, Tumor - blood
complement C4-A
Complement C4a - metabolism
Endocrinology
Female
Humans
Male
Middle Aged
papillary thyroid carcinoma
plasminogen
Plasminogen - metabolism
prediction
Proteomics
Sensitivity and Specificity
Thyroid Cancer, Papillary - blood
Thyroid Cancer, Papillary - diagnosis
Thyroid Cancer, Papillary - pathology
Thyroid Neoplasms - blood
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
title Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma
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