Laboratory parameters in lean NAFLD: comparison of subjects with lean NAFLD with obese subjects without hepatic steatosis

Search for meaningful laboratory and anthropometric parameters in lean non-alcoholic fatty liver disease (lean NAFLD) in the general population. Out of 2445 subjects in a random population sample, we compared those who had a body mass index (BMI)  30 but no fatty liver [non-NAFLD (NN), n = 27] in a...

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Published in:BMC research notes 2018-02, Vol.11 (1), p.101-101, Article 101
Main Authors: Bernhardt, Philipp, Kratzer, Wolfgang, Schmidberger, Julian, Graeter, Tilmann, Gruener, Beate
Format: Article
Language:English
Subjects:
Alcohol
Body mass index
Body weight
Cholesterol
Development and progression
Fat metabolism
Fatty liver
Ferritin
Haematocrit
Haemoglobin
Health aspects
Hematocrit
Hemoglobin
Hemoglobins
Insulin
Insulin resistance
Iron
lean NAFLD
Liver diseases
Mean corpuscular haemoglobin concentration
Measurement
Metabolism
Obesity
Overweight
Research Note
Steatosis
Thyroid gland
Triglycerides
Ultrasonic imaging
Waist-to-hip ratio
Womens health
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cited_by cdi_FETCH-LOGICAL-c5091-6781316f99888338afb45a47ce9ee2b774421ffbad8bfed33bbcbafe12c8768c3
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description Search for meaningful laboratory and anthropometric parameters in lean non-alcoholic fatty liver disease (lean NAFLD) in the general population. Out of 2445 subjects in a random population sample, we compared those who had a body mass index (BMI)  30 but no fatty liver [non-NAFLD (NN), n = 27] in a follow-up examination. Ultrasonic, anthropometric and laboratory parameters were collected. There were significant differences (p 
doi_str_mv 10.1186/s13104-018-3212-1
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Out of 2445 subjects in a random population sample, we compared those who had a body mass index (BMI) &lt; 25 and a fatty liver [lean NAFLD (LN), n = 5] with obese subjects who had a BMI &gt; 30 but no fatty liver [non-NAFLD (NN), n = 27] in a follow-up examination. Ultrasonic, anthropometric and laboratory parameters were collected. There were significant differences (p &lt; 0.05) between the LN and the NN groups with respect to serum ferritin (199.2 ± 72.1 LN vs 106.0 ± 89.6 NN), haemoglobin (14.9 ± 0.8 LN vs 13.5 ± 1.2 NN), haematocrit (0.438 ± 0.019 LN vs 0.407 ± 0.035 NN) and Mean corpuscular haemoglobin concentration (34 ± 0.6 LN vs 33.2 ± 0.8 NN). Significantly lower values of soluble transferrin receptor were measured in the LN group (2.8 ± 0.4 LN vs 3.8 ± 1.5 NN). In both groups, the measured HOMA-IR index (homeostatic model assessment of insulin resistance index) (2.3; normal range ≤ 1) was abnormal. Mean cholesterol (6.2 ± 1.4 LN and 5.6 ± 1.1 NN) and low-density lipoprotein levels (3.8 ± 1.0 LN 3.4 ± 0.9 NN) were above the upper limit of normal in both groups, as was the mean triglycerides level in the LN group (2.6 ± 2.0). 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Out of 2445 subjects in a random population sample, we compared those who had a body mass index (BMI) &lt; 25 and a fatty liver [lean NAFLD (LN), n = 5] with obese subjects who had a BMI &gt; 30 but no fatty liver [non-NAFLD (NN), n = 27] in a follow-up examination. Ultrasonic, anthropometric and laboratory parameters were collected. There were significant differences (p &lt; 0.05) between the LN and the NN groups with respect to serum ferritin (199.2 ± 72.1 LN vs 106.0 ± 89.6 NN), haemoglobin (14.9 ± 0.8 LN vs 13.5 ± 1.2 NN), haematocrit (0.438 ± 0.019 LN vs 0.407 ± 0.035 NN) and Mean corpuscular haemoglobin concentration (34 ± 0.6 LN vs 33.2 ± 0.8 NN). Significantly lower values of soluble transferrin receptor were measured in the LN group (2.8 ± 0.4 LN vs 3.8 ± 1.5 NN). In both groups, the measured HOMA-IR index (homeostatic model assessment of insulin resistance index) (2.3; normal range ≤ 1) was abnormal. Mean cholesterol (6.2 ± 1.4 LN and 5.6 ± 1.1 NN) and low-density lipoprotein levels (3.8 ± 1.0 LN 3.4 ± 0.9 NN) were above the upper limit of normal in both groups, as was the mean triglycerides level in the LN group (2.6 ± 2.0). In summary, there are differences in parameters of iron and fat metabolism between subjects with LN and overweight subjects without fatty liver infiltration.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>29409538</pmid><doi>10.1186/s13104-018-3212-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Alcohol
Body mass index
Body weight
Cholesterol
Development and progression
Fat metabolism
Fatty liver
Ferritin
Haematocrit
Haemoglobin
Health aspects
Hematocrit
Hemoglobin
Hemoglobins
Insulin
Insulin resistance
Iron
lean NAFLD
Liver diseases
Mean corpuscular haemoglobin concentration
Measurement
Metabolism
Obesity
Overweight
Research Note
Steatosis
Thyroid gland
Triglycerides
Ultrasonic imaging
Waist-to-hip ratio
Womens health
title Laboratory parameters in lean NAFLD: comparison of subjects with lean NAFLD with obese subjects without hepatic steatosis
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