Autophagy in prostate cancer and androgen suppression therapy

The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cance...

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Published in:International journal of molecular sciences 2013-06, Vol.14 (6), p.12090-12106
Main Authors: Ziparo, Elio, Petrungaro, Simonetta, Marini, Elettra Sara, Starace, Donatella, Conti, Silvia, Facchiano, Antonio, Filippini, Antonio, Giampietri, Claudia
Format: Article
Language:English
Subjects:
androgen deprivation therapy
Androgens - pharmacology
Androgens - therapeutic use
Animals
apoptosis
autophagy
Autophagy - drug effects
Cancer
Disease Progression
Humans
Immunity - drug effects
Life Sciences
Male
Models, Biological
prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - immunology
Prostatic Neoplasms - pathology
Review
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cited_by cdi_FETCH-LOGICAL-c585t-8fc257dbc6b0883b30b86478bddc45444c2b6de437933c71e448787c7d764ea93
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container_issue 6
container_start_page 12090
container_title International journal of molecular sciences
container_volume 14
creator Ziparo, Elio
Petrungaro, Simonetta
Marini, Elettra Sara
Starace, Donatella
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Filippini, Antonio
Giampietri, Claudia
description The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.
doi_str_mv 10.3390/ijms140612090
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subjects androgen deprivation therapy
Androgens - pharmacology
Androgens - therapeutic use
Animals
apoptosis
autophagy
Autophagy - drug effects
Cancer
Disease Progression
Humans
Immunity - drug effects
Life Sciences
Male
Models, Biological
prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - immunology
Prostatic Neoplasms - pathology
Review
title Autophagy in prostate cancer and androgen suppression therapy
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