Assessing the Influence of Low Doses of Sucrose on Memory Deficits in Fish Exposed to Common Insecticide Based on Fipronil and Pyriproxyfen

Although pesticides have been a constant concern for decades, in the last ten years, public discussions and scientific research have emphasized their impact on human health and the environment, drawing increased attention to the problems associated with their use. The association of environmental st...

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Published in:Current issues in molecular biology 2024-12, Vol.46 (12), p.14168-14189
Main Authors: Rarinca, Viorica, Hritcu, Luminita Diana, Burducea, Marian, Plavan, Gabriel, Lefter, Radu, Burlui, Vasile, Romila, Laura, Ciobică, Alin, Todirascu-Ciornea, Elena, Barbacariu, Cristian-Alin
Format: Article
Language:English
Subjects:
common insecticide
fipronil
memory deficits
pyriproxyfen
Silver crucian carp
sucrose
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Summary:Although pesticides have been a constant concern for decades, in the last ten years, public discussions and scientific research have emphasized their impact on human health and the environment, drawing increased attention to the problems associated with their use. The association of environmental stressors such as pesticides with a sugar-rich diet can contribute to the growing global metabolic disease epidemic through overlapping mechanisms of insulin resistance, inflammation, and metabolic dysregulation. The main aim of this study was to evaluate the behavioral effects of the exposure of Silver crucian carp ( ) to a commercial insecticide formulation containing fipronil, pyriproxyfen, and other additives, as well as sucrose and their mixtures. The behavioral responses in the T-test showed significant abnormalities in the exploratory activity evocative of memory deficits and an increased degree of anxiety in the groups of fish treated with the insecticide formulation and the mixture of the insecticide with sucrose. Aggression, quantified in the mirror-biting test, as biting and the frequency of approaches to the mirror contact zone, was significantly decreased only in the insecticide and sucrose group. All three groups showed behavioral changes reflective of toxicity, but only the combination of the two stress factors, environmental (insecticide) and metabolic (sucrose intake), resulted in pronounced memory alterations.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb46120848