Niacin supplementation attenuates the regression of three-dimensional capillary architecture in unloaded female rat skeletal muscle

Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this capillary regression. In this study involving adult female Sprague-Dawley rats, the animals were randomly assigned to one of four groups: control...

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Bibliographic Details
Published in:Physiological reports 2024-04, Vol.12 (8), p.e16019-e16019
Main Authors: Lin, Hao, Xing, Jihao, Pan, Han, Hirabayashi, Takumi, Maeshige, Noriaki, Nakanishi, Ryosuke, Kondo, Hiroyo, Fujino, Hidemi
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Animals
Atrophy
Biosynthesis
Blood vessels
capillary regression
Dietary Supplements
Female
Hindlimb Suspension - methods
mitochondrial metabolism
muscle atrophy
Muscle, Skeletal - metabolism
Muscular Atrophy - metabolism
Musculoskeletal system
niacin
Niacin - metabolism
Niacin - pharmacology
Niacin - therapeutic use
Nicotinic acid
Oral administration
Original
Rats
Rats, Sprague-Dawley
Skeletal muscle
Soleus muscle
Succinate dehydrogenase
Supplements
Unloading
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Summary:Inactivity can lead to muscle atrophy and capillary regression in skeletal muscle. Niacin (NA), known for inducing hypermetabolism, may help prevent this capillary regression. In this study involving adult female Sprague-Dawley rats, the animals were randomly assigned to one of four groups: control (CON), hindlimb unloading (HU), NA, and HU with NA supplementation (HU + NA). For a period of 2 weeks, the rats in the HU and HU + NA groups underwent HU, while those in the NA and HU + NA groups received NA (750 mg/kg) twice daily through oral administration. The results demonstrated that HU lowered capillary number, luminal diameter, and capillary volume, as well as decreased succinate dehydrogenase activity, slow fiber composition, and PGC-1α expression within the soleus muscle. However, NA supplementation prevented these alterations in capillary structure due to unloading by stimulating PGC-1α factors and inhibiting mitochondrial dysfunction. Therefore, NA supplementation could serve as a potential therapeutic approach for preserving the capillary network and mitochondrial metabolism of muscle fibers during periods of inactivity.
ISSN:2051-817X
DOI:10.14814/phy2.16019