CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections

Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of chemokine expression helps shape the immune res...

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Bibliographic Details
Published in:Viruses 2022-11, Vol.14 (11), p.2445
Main Authors: Elemam, Noha Mousaad, Talaat, Iman Mamdouh, Maghazachi, Azzam A
Format: Article
Language:English
Subjects:
Angiogenesis
Cell adhesion & migration
Chemokine CXCL10 - genetics
Chemokines
CXCL10
CXCL10 protein
CXCR3 protein
Cytokines
Dengue fever
Deoxyribonucleic acid
Development and progression
DNA
DNA viruses
Fibroblasts
Health aspects
Hepatitis
HIV
Human immunodeficiency virus
Humans
Immune clearance
Immune response
Infections
Inflammation
Influenza
Interferon
Kinases
Leukocyte migration
Lymphocytes
Proteins
Regulation
Review
Ribonucleic acid
RNA
RNA viruses
Tumor necrosis factor-TNF
Viral infections
Virus diseases
Virus Diseases - genetics
Viruses
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Summary:Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of chemokine expression helps shape the immune response and regulate viral clearance, improving clinical outcome. In particular, the chemokine ligand CXCL10 and its receptor CXCR3 were explored in a plethora of RNA and DNA viral infections. In this review, we highlight the expression profile and role of the CXCL10/CXCR3 axis in the host defense against a variety of RNA and DNA viral infections. We also discuss the interactions among viruses and host cells that trigger CXCL10 expression, as well as the signaling cascades induced in CXCR3 positive cells.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14112445