Novel genetic association of the Furin gene polymorphism rs1981458 with COVID-19 severity among Indian populations

SARS CoV-2, the causative agent for the ongoing COVID-19 pandemic, it enters the host cell by activating the ACE2 receptor with the help of two proteasesi.e., Furin and TMPRSS2. Therefore, variations in these genes may account for differential susceptibility and severity between populations. Previou...

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Bibliographic Details
Published in:Scientific reports 2024-04, Vol.14 (1), p.7822-7822, Article 7822
Main Authors: Pandey, Rudra Kumar, Srivastava, Anshika, Mishra, Rahul Kumar, Singh, Prajjval Pratap, Chaubey, Gyaneshwer
Format: Article
Language:English
Subjects:
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ACE2
Affinity
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - genetics
COVID-19
COVID-19 - epidemiology
COVID-19 - genetics
Epidemiology
Furin
Furin - genetics
Gene polymorphism
Genes
Genetic diversity
Genetic structure
Genetic variance
Humanities and Social Sciences
Humans
Hypertension
Minority & ethnic groups
multidisciplinary
Next-generation sequencing
Pandemics
Phylogeography
Polymorphism, Genetic
Population studies
Quantitative trait loci
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Susceptibility
World population
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Summary:SARS CoV-2, the causative agent for the ongoing COVID-19 pandemic, it enters the host cell by activating the ACE2 receptor with the help of two proteasesi.e., Furin and TMPRSS2. Therefore, variations in these genes may account for differential susceptibility and severity between populations. Previous studies have shown that the role of ACE2 and TMPRSS2 gene variants in understanding COVID-19 susceptibility among Indian populations. Nevertheless, a knowledge gap exists concerning the COVID-19 susceptibility of Furin gene variants among diverse South Asian ethnic groups. Investigating the role of Furin gene variants and their global phylogeographic structure is essential to comprehensively understanding COVID-19 susceptibility in these populations. We have used 450 samples from diverse Indian states and performed linear regression to analyse the Furin gene variant's with COVID-19 Case Fatality Rate (CFR) that could be epidemiologically associated with disease severity outcomes. Associated genetic variants were further evaluated for their expression and regulatory potential through various Insilco analyses. Additionally, we examined the Furin gene using next-generation sequencing (NGS) data from 393 diverse global samples, with a particular emphasis on South Asia, to investigate its Phylogeographic structure among diverse world populations. We found a significant positive association for the SNP rs1981458 with COVID-19 CFR (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-54607-7