Significance of CD44 and CD24 as Cancer Stem Cell Markers : An Enduring Ambiguity

Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CS...

Full description

Saved in:
Bibliographic Details
Published in:Clinical & developmental immunology 2012-01, Vol.2012 (2012), p.1-11
Main Authors: Jaggupilli, Appalaraju, Elkord, Eyad
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biomedical research
Cancer
CD24 Antigen - genetics
CD24 Antigen - metabolism
CD44 antigen
Female
Gene Expression Regulation, Neoplastic
Genotype & phenotype
Heat
Humans
Hyaluronan Receptors - genetics
Hyaluronan Receptors - metabolism
Hyaluronic acid
Immunology
Life sciences
Male
Metastases
Mutation
Neoplasm Metastasis - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Review
Reviews
Stem cells
Studies
Surface markers
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer stem cell population is a subset of cells capable of dictating invasion, metastasis, heterogeneity, and therapeutic resistance in tumours. Eradication of this rare population is a new insight in cancer treatment. However, prospective identification, characterization, and isolation of these CSCs have been a major challenge. Many studies were performed on surface markers for potential identification and isolation of CSCs. Lack of universal expression of surface markers limits their usage and no best combination of markers has yet been confirmed to identify CSCs capable of initiating and metastasizing tumours. CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker expressed in many tumour types. However, their expression and prognostic value in isolating CSCs are still an enduring ambiguity. In this critical review, we assess the role of CD44 and CD24 in tumour initiation, development, and metastasis. We mainly focus on analysing the significance of CD44 and CD24 as CSC surface markers in combination or with other putative markers in different types of cancer.
ISSN:1740-2522
2314-8861
1740-2530
2314-7156
DOI:10.1155/2012/708036