Paternal Mitochondrial DNA Leakage in Natural Populations of Large-Scale Loach, Paramisgurnus dabryanus

Animal mitochondrial DNA is usually considered to comply with strict maternal inheritance, and only one mitochondrial DNA haplotype exists in an individual. However, mitochondrial heteroplasmy, the occurrence of more than one mitochondrial haplotype, has recently been reported in some animals, such...

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Bibliographic Details
Published in:Biology (Basel, Switzerland) Switzerland), 2024-08, Vol.13 (8), p.604
Main Authors: Qi, Zixin, Shi, Jiaoxu, Yu, Yue, Yin, Guangmei, Zhou, Xiaoyun, Yu, Yongyao
Format: Article
Language:English
Subjects:
Bioinformatics
Copy number
DNA sequencing
Evolutionary genetics
Fish
Genes
Genetic engineering
Genomes
Genomics
Haplotypes
Heteroplasmy
Interspecific hybridization
Maternal inheritance
Mitochondria
Mitochondrial DNA
Next-generation sequencing
Nucleotide sequence
P. dabryanus
Paramisgurnus dabryanus
paternal leakage
Phylogenetics
Phylogeny
Population studies
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Summary:Animal mitochondrial DNA is usually considered to comply with strict maternal inheritance, and only one mitochondrial DNA haplotype exists in an individual. However, mitochondrial heteroplasmy, the occurrence of more than one mitochondrial haplotype, has recently been reported in some animals, such as mice, mussels, and birds. This study conducted extensive field surveys to obtain representative samples to investigate the existence of paternal inheritance of mitochondrial DNA (mtDNA) in natural fish populations. Evidence of paternal mitochondrial DNA leakage of was discovered using high-throughput sequencing and bioinformatics methods. Two distinct mitochondrial haplotypes (16,569 bp for haplotype I and 16,646 bp for haplotype II) were observed, differing by 18.83% in nucleotide sequence. Phylogenetic analysis suggests divergence between these haplotypes and potential interspecific hybridization with , leading to paternal leakage. In natural populations of along the Yangtze River, both haplotypes are present, with Type I being dominant (75% copy number). Expression analysis shows that Type I has higher expression levels of and genes compared to Type II, suggesting Type I's primary role. This discovery of a species with two mitochondrial types provides a model for studying paternal leakage heterogeneity and insights into mitochondrial genome evolution and inheritance.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology13080604