New Insights Into Physiological and Pathophysiological Functions of Stanniocalcin 2

Stanniocalcin, a glycosylated peptide hormone, first discovered in a bony fish has originally been shown to play critical role in calcium and phosphate homeostasis. Two paralogs of stanniocalcin ( and ) identified in mammals are widely expressed in variety of tissues. This review provides historical...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2020-03, Vol.11, p.172
Main Author: Joshi, Aditya D
Format: Article
Language:English
Subjects:
Amino Acid Sequence
angiogenesis
Animals
apoptosis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - physiology
Calcium - metabolism
calcium regulation
Cloning, Molecular
cytoprotection
development
Endocrinology
Fishes - genetics
Fishes - metabolism
Glycoproteins - genetics
Glycoproteins - physiology
Humans
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - physiology
Mammals - genetics
Mammals - metabolism
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - metabolism
Phosphates - metabolism
Phylogeny
stanniocalcin 2
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Summary:Stanniocalcin, a glycosylated peptide hormone, first discovered in a bony fish has originally been shown to play critical role in calcium and phosphate homeostasis. Two paralogs of stanniocalcin ( and ) identified in mammals are widely expressed in variety of tissues. This review provides historical perspective on the discovery of fish and mammalian stanniocalcin, describes molecular regulation of gene, catalogs distribution as well as expression of STC2 in tissues, and provides key structural information known till date regarding mammalian STC2. Additionally, this mini review summarizes pivotal functions of STC2 in calcium and phosphate regulation, cytoprotection, cell development, and angiogenesis. Finally, STC2's role as a novel marker for human cancers has also been outlined. Reviewing these studies will provide an opportunity to understand STC2's structure, biological functions as well as key molecular pathways involving STC2, which will help us design innovative therapeutic interventions using this novel hormone.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2020.00172