Coronavirus Proteins as Ion Channels: Current and Potential Research

Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Resp...

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Bibliographic Details
Published in:Frontiers in immunology 2020-10, Vol.11, p.573339-573339
Main Authors: McClenaghan, Conor, Hanson, Alex, Lee, Sun-Joo, Nichols, Colin G
Format: Article
Language:English
Subjects:
Animals
bilayer
electrophysiology
Humans
Immunology
ion channel
Ion Channels - genetics
Ion Channels - metabolism
SARS Virus - genetics
SARS Virus - metabolism
Severe Acute Respiratory Syndrome - virology
Severe Acute Respiratory Syndrome coronavirus
Severe Acute Respiratory Syndrome coronavirus-2
spike protein
Viral Envelope Proteins - genetics
Viral Envelope Proteins - metabolism
Viral Proteins - genetics
Viral Proteins - metabolism
Viroporin Proteins - genetics
Viroporin Proteins - metabolism
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Summary:Coronavirus (CoV) outbreaks have recently emerged as a global public health threat due to their exceptional zoonotic potential - a feature arising from their ability to infect a diverse range of potential hosts combined with their high capacity for mutation and recombination. After Severe Acute Respiratory Syndrome (SARS) CoV-1 in 2003 and Middle East Respiratory Syndrome (MERS) CoV in 2012, with the current SARS-CoV-2 pandemic we are now in the midst of the third deadly international CoV outbreak in less than 20 years. Coronavirus outbreaks present a critical threat to global public health and an urgent necessity for therapeutic options. Here, we critically examine the current evidence for ion channel activity in CoV proteins and the potential for modulation as a therapeutic approach.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.573339