Pre- and postnatal MR imaging of an asymptomatic giant hypothalamic hamartoma

Hypothalamic hamartomas are rare tumors that are most often diagnosed in early childhood. These lesions are classified as giant hypothalamic hamartomas when they exceed 4 cm in any 1 dimension. The most common presenting symptoms associated with these lesions are precocious puberty, gelastic seizure...

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Bibliographic Details
Published in:Radiology case reports 2020-08, Vol.15 (8), p.1250-1255
Main Authors: Cristobal, Alberto, Vorona, Gregory, Ritter, Ann, Lanni, Susan, Urbine, Jacqueline
Format: Article
Language:English
Subjects:
Giant hypothalamic hamartoma
MRI
Neonate
Neuroradiology
Prenatal
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Summary:Hypothalamic hamartomas are rare tumors that are most often diagnosed in early childhood. These lesions are classified as giant hypothalamic hamartomas when they exceed 4 cm in any 1 dimension. The most common presenting symptoms associated with these lesions are precocious puberty, gelastic seizures, and (less commonly) syndromic conditions such as Pallister-Hall syndrome. We present a unique case of an asymptomatic giant hypothalamic hamartoma diagnosed prenatally by fetal magnetic resonance imaging and followed throughout infancy. This case demonstrates the utility of multimetric analysis using difference sequences, including diffuse-weighted imaging, to assess specific properties of intracranial lesions detected in utero and to aid in accurate diagnosis prior to birth.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2020.05.041