Approaching Sex Differences in Cardiovascular Non-Coding RNA Research

Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly und...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-07, Vol.21 (14), p.4890
Main Authors: Jusic, Amela, Salgado-Somoza, Antonio, Paes, Ana B, Stefanizzi, Francesca Maria, Martínez-Alarcón, Núria, Pinet, Florence, Martelli, Fabio, Devaux, Yvan, Robinson, Emma Louise, Novella, Susana, On Behalf Of The Eu-CardioRNA Cost Action
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Cardiology and cardiovascular system
cardiovascular diseases
Cardiovascular Diseases - genetics
Cardiovascular Diseases - metabolism
Cardiovascular System - metabolism
experimental models
Human health and pathology
Humans
Life Sciences
lncRNA
miRNA
ncRNA
Review
RNA, Untranslated - genetics
Sex Characteristics
vascular cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly understood. Non-coding RNAs (ncRNAs) are emerging as key mediators and biomarkers of CVD. Similarly, current knowledge on differential regulation, expression, and pathology-associated function of ncRNAs between sexes is minimal. Here, we provide a state-of-the-art overview of what is known on sex differences in ncRNA research in CVD as well as discussing the contributing biological factors to this sex dimorphism including genetic and epigenetic factors and sex hormone regulation of transcription. We then focus on the experimental models of CVD and their use in translational ncRNA research in the cardiovascular field. In particular, we want to highlight the importance of considering sex of the cellular and pre-clinical models in clinical studies in ncRNA research and to carefully consider the appropriate experimental models most applicable to human patient populations. Moreover, we aim to identify sex-specific targets for treatment and diagnosis for the biggest socioeconomic health problem globally.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21144890