Temperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2- iso -butyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline)-Based Thermogelling Hydrogel

The synthesis and characterization of an ABA triblock copolymer based on hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks A and a modestly hydrophobic poly(2- -butyl-2-oxazoline) (p BuOx) block B is described. Aqueous polymer solutions were prepared at different concentrations (1-20 wt %) and t...

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Bibliographic Details
Published in:Journal of functional biomaterials 2019-08, Vol.10 (3), p.36
Main Authors: Lübtow, Michael M, Mrlik, Miroslav, Hahn, Lukas, Altmann, Alexander, Beudert, Matthias, Lühmann, Tessa, Luxenhofer, Robert
Format: Article
Language:English
Subjects:
Abscisic acid
amphiphilic block copolymer
Biomedical materials
Block copolymers
Cellulose acetate
Chromatography
cytocompatibility
Cytotoxicity
Gels
Hydrogels
Hydrophobicity
Investigations
NMR
Nuclear magnetic resonance
poly(2-oxazoline), viscoelasticity
Polymerization
Polymers
Rheological properties
Rheology
Shear stress
Shear thinning (liquids)
Solvents
Spectrum analysis
Temperature dependence
thermoresponsive hydrogel
Three dimensional printing
Toxicity
Viscoelasticity
Viscosity
Visual observation
Yield stress
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Summary:The synthesis and characterization of an ABA triblock copolymer based on hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks A and a modestly hydrophobic poly(2- -butyl-2-oxazoline) (p BuOx) block B is described. Aqueous polymer solutions were prepared at different concentrations (1-20 wt %) and their thermogelling capability using visual observation was investigated at different temperatures ranging from 5 to 80 °C. As only a 20 wt % solution was found to undergo thermogelation, this concentration was investigated in more detail regarding its temperature-dependent viscoelastic profile utilizing various modes (strain or temperature sweep). The prepared hydrogels from this particular ABA triblock copolymer have interesting rheological and viscoelastic properties, such as reversible thermogelling and shear thinning, and may be used as bioink, which was supported by its very low cytotoxicity and initial printing experiments using the hydrogels. However, the soft character and low yield stress of the gels do not allow real 3D printing at this point.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb10030036