Degeneration of human photosensitive retinal ganglion cells may explain sleep and circadian rhythms disorders in Parkinson's disease

Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these processes and may be affected in PD, as other...

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Bibliographic Details
Published in:Acta neuropathologica communications 2018-09, Vol.6 (1), p.90-90, Article 90
Main Authors: Ortuño-Lizarán, Isabel, Esquiva, Gema, Beach, Thomas G, Serrano, Geidy E, Adler, Charles H, Lax, Pedro, Cuenca, Nicolás
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis
Brain research
Chronobiology Disorders - etiology
Chronobiology Disorders - pathology
Circadian rhythms
Cognition & reasoning
Diabetic retinopathy
Disease
Female
Ganglion cysts
Human
Humans
Immunohistochemistry
Male
Melanopsin retinal ganglion cell
Melatonin
Morphology
Nerve Degeneration - etiology
Nervous system
Parkinson Disease - complications
Parkinson's disease
Pathology
Physiological aspects
Quality of life
Retina
Retinal Ganglion Cells - metabolism
Retinal Ganglion Cells - pathology
Rod Opsins - metabolism
Sleep
Sleep disorders
Sleep Wake Disorders - etiology
Sleep Wake Disorders - pathology
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Summary:Parkinson's disease (PD) patients often suffer from non-motor symptoms like sleep dysregulation, mood disturbances or circadian rhythms dysfunction. The melanopsin-containing retinal ganglion cells are involved in the control and regulation of these processes and may be affected in PD, as other retinal and visual implications have been described in the disease. Number and morphology of human melanopsin-containing retinal ganglion cells were evaluated by immunohistochemistry in eyes from donors with PD or control. The Sholl number of intersections, the number of branches, and the number of terminals from the Sholl analysis were significantly reduced in PD melanopsin ganglion cells. Also, the density of these cells significantly decreased in PD compared to controls. Degeneration and impairment of the retinal melanopsin system may affect to sleep and circadian dysfunction reported in PD pathology, and its protection or stimulation may lead to better disease prospect and global quality of life of patients.
ISSN:2051-5960
2051-5960
DOI:10.1186/s40478-018-0596-z