Effect of occupational exposure to lead on serum levels of lipid profile and liver enzymes: An occupational cohort study

The present study was performed to know the effects of chronic lead exposure on serum lipids, lipoproteins, and liver enzymes in a cohort study among of lead mine workers. We followed of 200 Iranian workers for 3- years (2018–2020), 100 of them with known occupational exposure to lead thorough their...

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Bibliographic Details
Published in:Toxicology reports 2022-01, Vol.9, p.269-275
Main Authors: Firoozichahak, Ali, Rahimnejad, Samira, Rahmani, Abdolrasoul, Parvizimehr, Ali, Aghaei, Abbas, Rahimpoor, Razzagh
Format: Article
Language:English
Subjects:
Biomarkers
Lead Poisoning, Occupational Exposure, Liver Function Test
Mines
Regular
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Summary:The present study was performed to know the effects of chronic lead exposure on serum lipids, lipoproteins, and liver enzymes in a cohort study among of lead mine workers. We followed of 200 Iranian workers for 3- years (2018–2020), 100 of them with known occupational exposure to lead thorough their work in lead mine while the others 100 were with no such exposure. Blood lead level (BLL), serum lipids, lipoproteins, and liver enzymes of the exposure group for 3- years were measured and compared with those attained in the non-exposed workers. The BLL levels of the lead-mine workers were higher than with recommended level and the non-exposed group (24.15 and 6.35 µg/dL, respectively). The findings indicated a positive and significant relationship between BLL and lactate dehydrogenase, aspartate transaminase, alkaline phosphatase, alanine transaminase, and bilirubin levels (P 
ISSN:2214-7500
2214-7500
DOI:10.1016/j.toxrep.2022.02.009