Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1

Dysregulated mitochondrial dynamics and biogenesis have been associated with various pathological conditions including cancers. Here, we assessed the therapeutic effect of cryptolepine, a pharmacologically active alkaloid derived from the roots of Cryptolepis sanguinolenta , on melanoma cell growth....

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Bibliographic Details
Published in:Scientific reports 2017-05, Vol.7 (1), p.1498-15, Article 1498
Main Authors: Pal, Harish C., Prasad, Ram, Katiyar, Santosh K.
Format: Article
Language:English
Subjects:
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Adenosine Triphosphate - metabolism
Adenylate Kinase - metabolism
Animals
Biosynthesis
Body weight
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival - drug effects
Clone Cells
Female
Humanities and Social Sciences
Indole Alkaloids - administration & dosage
Indole Alkaloids - pharmacology
LKB1 protein
Melanocytes
Melanocytes - drug effects
Melanocytes - metabolism
Melanocytes - pathology
Melanoma
Melanoma - enzymology
Melanoma - pathology
Membrane potential
Membrane Potential, Mitochondrial - drug effects
Membrane proteins
Metabolic rate
Metabolism
Mice, Nude
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Mitochondrial DNA
Mitochondrial Dynamics - drug effects
Models, Biological
multidisciplinary
Organelle Biogenesis
Phosphorylation - drug effects
Protein Biosynthesis - drug effects
Protein-Serine-Threonine Kinases - metabolism
Quinolines - administration & dosage
Quinolines - pharmacology
Science
Science (multidisciplinary)
Signal Transduction - drug effects
TOR protein
TOR Serine-Threonine Kinases - metabolism
Toxicity
Tumor suppressor genes
Tumor Suppressor Proteins - metabolism
Xenograft Model Antitumor Assays
Xenografts
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Summary:Dysregulated mitochondrial dynamics and biogenesis have been associated with various pathological conditions including cancers. Here, we assessed the therapeutic effect of cryptolepine, a pharmacologically active alkaloid derived from the roots of Cryptolepis sanguinolenta , on melanoma cell growth. Treatment of human melanoma cell lines (A375, Hs294t, SK-Mel28 and SK-Mel119) with cryptolepine (1.0, 2.5, 5.0 and 7.5 μM) for 24 and 48 h significantly ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-01659-7