Association of UGT1A16, UGT1A128, or ABCC2 c.3972C>T genetic polymorphisms with irinotecan‐induced toxicity in Asian cancer patients: Meta‐analysis

Effects of UGT1A1*6 and UGT1A1*28 genetic polymorphisms on irinotecan‐induced severe toxicities in Asian cancer patients are inconclusive. Also, ABCC2 c.3972C>T may affect toxicity of irinotecan. The aim was to assess the aggregated risk of neutropenia or diarrhea in Asian cancer patients taking...

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Published in:Clinical and translational science 2022-07, Vol.15 (7), p.1613-1633
Main Authors: Atasilp, Chalirmporn, Biswas, Mohitosh, Jinda, Pimonpan, Nuntharadthanaphong, Nutthan, Rachanakul, Jiratha, Hongkaew, Yaowaluck, Vanwong, Natchaya, Saokaew, Surasak, Sukasem, Chonlaphat
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Cancer
Cancer therapies
Diarrhea
Diarrhea - chemically induced
Diarrhea - genetics
Enzymes
Gene polymorphism
Genetic diversity
Genotype
Glucuronosyltransferase - genetics
Humans
Irinotecan
Irinotecan - adverse effects
Irinotecan - therapeutic use
Meta-analysis
Neoplasms - drug therapy
Neutropenia
Neutropenia - chemically induced
Neutropenia - genetics
Polymorphism
Polymorphism, Genetic
Statistical analysis
Topoisomerase I Inhibitors - adverse effects
Topoisomerase I Inhibitors - therapeutic use
Toxicity
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Summary:Effects of UGT1A1*6 and UGT1A1*28 genetic polymorphisms on irinotecan‐induced severe toxicities in Asian cancer patients are inconclusive. Also, ABCC2 c.3972C>T may affect toxicity of irinotecan. The aim was to assess the aggregated risk of neutropenia or diarrhea in Asian cancer patients taking irinotecan and inherited UGT1A1*6, UGT1A1*28, or ABCC2 c.3972C>T genetic variants. A PubMed literature search for eligible studies was conducted. Odds ratios (ORs) were measured using RevMan software where p values
ISSN:1752-8054
1752-8062
1752-8062
DOI:10.1111/cts.13277