Construction of isoniazid pharmaceutical logic system based on poly(N, N-diethylacrylamide) hydrogel films

• Published in: Sensors and actuators reports 2023-06, Vol.5, p.100147, Article 100147
• Main Authors: Shi, Keren, Liang, Xiangming, Li, Mingming, Zhai, Zhenhua, Liu, Ying, Shan, Xiaoyan, Ma, Yang, Gan, Qianqian, Yao, Huiqin
• Format: Article
• Language: English
• Subjects: Isoniazid; Logic gate; Multiple-stimuli responsive properties; poly(N,N-diethylacrylamide) hydrogel films; Switchable
• ISSN: 2666-0539; 2666-0539
• DOI: 10.1016/j.snr.2023.100147

•Drug molecule isoniazid (INH) showed multiple-stimuli-responsive electrochemical behaviors on the poly(N,N-diethylacrylamide) (PDEA) hydrogel film electrodes.•A 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus responsive characteristics of the electrochemical response of INH. In this work, poly(N,N-diethylacrylamide) (PDEA) hydrogel films were polymerized on glassy carbon (GC) electrode surface, and isoniazid (INH) was chosen as an electroactive pharmaceutical molecule probe, aiming to investigate the switchable electrochemical behaviors of INH. Determining the contents of INH tablets under different external stimuli conditions and constructing its logic gate computing systems. The triple-sensitive electrochemical CV behaviors of INH on this film system toward pH, temperature and salt concentration were observed and explored. Thus, a 3-input/8-output combinational pharmaceutical logic gate network and a 3-to-8 decoder were designed and constructed based on the stimulus-responsive characteristics of the electrochemical response of INH on PDEA hydrogel-modified electrodes. Besides, the relationship between the oxidation peak current (Ipa) and concentration of INH (CINH) was studied by the differential pulse voltammetry (DPV) method. Apply this film system, and the INH tablets could be switchable detected. The construction of the logic-gate computing system based on isoniazid drug molecule may provide a novel approach and model to design new style drug sensors, which might be applied to intelligent medical diagnostics and drug release. [Display omitted]