Radiologic and clinical changes after denosumab treatment for giant cell tumors of the mobile spine: a quantitative study

Objectives To analyze the radiologic and clinical changes after denosumab treatment in patients with giant cell tumors (GCTs) in the mobile spine. Methods Clinical data and images by computed tomography and magnetic resonance imaging at a single center were retrospectively reviewed before and after...

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Bibliographic Details
Published in:Insights into imaging 2022-05, Vol.13 (1), p.93-93, Article 93
Main Authors: Yuan, Bei, Han, Songbo, Yang, Shaomin, Zhang, Lihua, Jiang, Liang, Wei, Feng, Yuan, Huishu, Liu, Xiaoguang, Liu, Zhongjun
Format: Article
Language:English
Subjects:
Computed tomography
Denosumab
Diagnostic Radiology
Giant cell tumor
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Monoclonal antibodies
Neuroradiology
Original
Original Article
Osteogenesis
Radiology
Shrinkage
Spinal cord
Tumors
Ultrasound
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Summary:Objectives To analyze the radiologic and clinical changes after denosumab treatment in patients with giant cell tumors (GCTs) in the mobile spine. Methods Clinical data and images by computed tomography and magnetic resonance imaging at a single center were retrospectively reviewed before and after denosumab treatment. Results Pre- and post-treatment data from 24 patients were evaluated. On imaging, marginal ossification and/or bone formation was observed in 22 patients (91.7%). The median maximum diameter of the GCT reduced from 52.5 to 48.2 mm ( p  
ISSN:1869-4101
1869-4101
DOI:10.1186/s13244-022-01226-3