Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells

Two new meroterpenoids, hyrtamide A ( ) and hyrfarnediol A ( ), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester ( ) and dictyoceratin C ( ), were isolated from a South China Sea sponge sp. Their structures were elucidated by NMR and MS data. Compounds - exhibited weak cytoto...

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Bibliographic Details
Published in:Marine drugs 2024-04, Vol.22 (4), p.183
Main Authors: Wang, Jie, Yan, Yue-Lu, Yu, Xin-Yi, Pan, Jia-Yan, Liu, Xin-Lian, Hong, Li-Li, Wang, Bin
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Anticancer properties
antineoplastic activity
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Antitumor activity
Cancer
Carbon
Cell cycle
Cell Line, Tumor
China
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - pathology
Cytotoxicity
Epithelial-Mesenchymal Transition - drug effects
Growth factors
HCT116 Cells
Humans
Hyrtios
Hyrtios sp
invasion
Marine invertebrates
marine sponge
Medical prognosis
meroterpenoids
Metastasis
Mortality
NMR
Nuclear magnetic resonance
p-Hydroxybenzoic acid
Porifera
Porifera - chemistry
South China Sea
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - pharmacology
Tumor cells
Vascular endothelial growth factor
vascular endothelial growth factor receptor-1
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Vascular endothelial growth factor receptors
VEGFR-1
Vimentin
Vimentin - metabolism
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Summary:Two new meroterpenoids, hyrtamide A ( ) and hyrfarnediol A ( ), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester ( ) and dictyoceratin C ( ), were isolated from a South China Sea sponge sp. Their structures were elucidated by NMR and MS data. Compounds - exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds and significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds and may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.
ISSN:1660-3397
1660-3397
DOI:10.3390/md22040183