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Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells
Two new meroterpenoids, hyrtamide A ( ) and hyrfarnediol A ( ), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester ( ) and dictyoceratin C ( ), were isolated from a South China Sea sponge sp. Their structures were elucidated by NMR and MS data. Compounds - exhibited weak cytoto...
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| Published in: | Marine drugs 2024-04, Vol.22 (4), p.183 |
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| creator | Wang, Jie Yan, Yue-Lu Yu, Xin-Yi Pan, Jia-Yan Liu, Xin-Lian Hong, Li-Li Wang, Bin |
| description | Two new meroterpenoids, hyrtamide A (
) and hyrfarnediol A (
), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (
) and dictyoceratin C (
), were isolated from a South China Sea sponge
sp. Their structures were elucidated by NMR and MS data. Compounds
-
exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC
values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds
and
significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds
and
may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT. |
| doi_str_mv | 10.3390/md22040183 |
| format | article |
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) and hyrfarnediol A (
), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (
) and dictyoceratin C (
), were isolated from a South China Sea sponge
sp. Their structures were elucidated by NMR and MS data. Compounds
-
exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC
values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds
and
significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds
and
may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.</description><identifier>ISSN: 1660-3397</identifier><identifier>EISSN: 1660-3397</identifier><identifier>DOI: 10.3390/md22040183</identifier><identifier>PMID: 38667800</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Animals ; Anticancer properties ; antineoplastic activity ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Cancer ; Carbon ; Cell cycle ; Cell Line, Tumor ; China ; Colorectal cancer ; Colorectal carcinoma ; colorectal neoplasms ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Cytotoxicity ; Epithelial-Mesenchymal Transition - drug effects ; Growth factors ; HCT116 Cells ; Humans ; Hyrtios ; Hyrtios sp ; invasion ; Marine invertebrates ; marine sponge ; Medical prognosis ; meroterpenoids ; Metastasis ; Mortality ; NMR ; Nuclear magnetic resonance ; p-Hydroxybenzoic acid ; Porifera ; Porifera - chemistry ; South China Sea ; Terpenes - chemistry ; Terpenes - isolation & purification ; Terpenes - pharmacology ; Tumor cells ; Vascular endothelial growth factor ; vascular endothelial growth factor receptor-1 ; Vascular Endothelial Growth Factor Receptor-1 - metabolism ; Vascular endothelial growth factor receptors ; VEGFR-1 ; Vimentin ; Vimentin - metabolism</subject><ispartof>Marine drugs, 2024-04, Vol.22 (4), p.183</ispartof><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c409t-7ea689b79723f45a6307b71273eee77201e9c749689c7b1b989548a3e05c98de3</cites><orcidid>0000-0002-2712-9045 ; 0000-0003-1457-5158 ; 0000-0002-2688-2369</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3046923052/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3046923052?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,25731,27901,27902,36989,36990,44566,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38667800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Yan, Yue-Lu</creatorcontrib><creatorcontrib>Yu, Xin-Yi</creatorcontrib><creatorcontrib>Pan, Jia-Yan</creatorcontrib><creatorcontrib>Liu, Xin-Lian</creatorcontrib><creatorcontrib>Hong, Li-Li</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><title>Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells</title><title>Marine drugs</title><addtitle>Mar Drugs</addtitle><description>Two new meroterpenoids, hyrtamide A (
) and hyrfarnediol A (
), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (
) and dictyoceratin C (
), were isolated from a South China Sea sponge
sp. Their structures were elucidated by NMR and MS data. Compounds
-
exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC
values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds
and
significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds
and
may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Anticancer properties</subject><subject>antineoplastic activity</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - isolation & purification</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>Cancer</subject><subject>Carbon</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>China</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>colorectal neoplasms</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cytotoxicity</subject><subject>Epithelial-Mesenchymal Transition - drug effects</subject><subject>Growth factors</subject><subject>HCT116 Cells</subject><subject>Humans</subject><subject>Hyrtios</subject><subject>Hyrtios sp</subject><subject>invasion</subject><subject>Marine invertebrates</subject><subject>marine sponge</subject><subject>Medical prognosis</subject><subject>meroterpenoids</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>p-Hydroxybenzoic acid</subject><subject>Porifera</subject><subject>Porifera - chemistry</subject><subject>South China Sea</subject><subject>Terpenes - chemistry</subject><subject>Terpenes - isolation & purification</subject><subject>Terpenes - pharmacology</subject><subject>Tumor cells</subject><subject>Vascular endothelial growth factor</subject><subject>vascular endothelial growth factor receptor-1</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - metabolism</subject><subject>Vascular endothelial growth factor receptors</subject><subject>VEGFR-1</subject><subject>Vimentin</subject><subject>Vimentin - metabolism</subject><issn>1660-3397</issn><issn>1660-3397</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqFkU1rFTEUhgdR7Idu_AEScCOFW_M1yWRZBvUWWlxY1yGTnLnmMpNMk4xw_72pt1Zx4yLkcHh44D1v07wh-JIxhT_MjlLMMenYs-aUCIE3dS2f_zWfNGc57zFmbaf4y-aEdULIDuPT5v4WUiyQFgjRu4zGFGd0a5IPgL4uMewAbQ-p-JhRXi6RCQ7dfQef0FUo3ppgoY62-B--HJDZGR9yQdt1NgH1cYoJbDET6o9gD9OUXzUvRjNleP34nzffPn2867ebmy-fr_urm43lWJWNBCM6NUglKRt5awTDcpCESgYAUlJMQFnJVYWsHMigOtXyzjDArVWdA3beXB-9Lpq9XpKfTTroaLz-tYhpp00NZifQjitwgwHOHeWjqDIBpj5BKKWSjtX1_uhaUrxfIRc9-2xrGhMgrlkz0rJWMsrE_1HMpWL19qyi7_5B93FNoR7lgRKKMtzSSl0cKZtizgnGpywE64f-9Z_-K_z2UbkOM7gn9Hfh7CeA_Ki6</recordid><startdate>20240419</startdate><enddate>20240419</enddate><creator>Wang, Jie</creator><creator>Yan, Yue-Lu</creator><creator>Yu, Xin-Yi</creator><creator>Pan, Jia-Yan</creator><creator>Liu, Xin-Lian</creator><creator>Hong, Li-Li</creator><creator>Wang, Bin</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T7</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H95</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2712-9045</orcidid><orcidid>https://orcid.org/0000-0003-1457-5158</orcidid><orcidid>https://orcid.org/0000-0002-2688-2369</orcidid></search><sort><creationdate>20240419</creationdate><title>Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells</title><author>Wang, Jie ; Yan, Yue-Lu ; Yu, Xin-Yi ; Pan, Jia-Yan ; Liu, Xin-Lian ; Hong, Li-Li ; Wang, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-7ea689b79723f45a6307b71273eee77201e9c749689c7b1b989548a3e05c98de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Anticancer properties</topic><topic>antineoplastic activity</topic><topic>Antineoplastic Agents - 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Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Marine drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jie</au><au>Yan, Yue-Lu</au><au>Yu, Xin-Yi</au><au>Pan, Jia-Yan</au><au>Liu, Xin-Lian</au><au>Hong, Li-Li</au><au>Wang, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells</atitle><jtitle>Marine drugs</jtitle><addtitle>Mar Drugs</addtitle><date>2024-04-19</date><risdate>2024</risdate><volume>22</volume><issue>4</issue><spage>183</spage><pages>183-</pages><issn>1660-3397</issn><eissn>1660-3397</eissn><abstract>Two new meroterpenoids, hyrtamide A (
) and hyrfarnediol A (
), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (
) and dictyoceratin C (
), were isolated from a South China Sea sponge
sp. Their structures were elucidated by NMR and MS data. Compounds
-
exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC
values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds
and
significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial-mesenchymal transition (EMT). Our findings suggest that compounds
and
may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38667800</pmid><doi>10.3390/md22040183</doi><orcidid>https://orcid.org/0000-0002-2712-9045</orcidid><orcidid>https://orcid.org/0000-0003-1457-5158</orcidid><orcidid>https://orcid.org/0000-0002-2688-2369</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Marine drugs, 2024-04, Vol.22 (4), p.183 |
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| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_d49edbae44d24f61b96ea96e6122272f |
| source | Publicly Available Content (ProQuest); PubMed Central |
| subjects | Angiogenesis Animals Anticancer properties antineoplastic activity Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Antitumor activity Cancer Carbon Cell cycle Cell Line, Tumor China Colorectal cancer Colorectal carcinoma colorectal neoplasms Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cytotoxicity Epithelial-Mesenchymal Transition - drug effects Growth factors HCT116 Cells Humans Hyrtios Hyrtios sp invasion Marine invertebrates marine sponge Medical prognosis meroterpenoids Metastasis Mortality NMR Nuclear magnetic resonance p-Hydroxybenzoic acid Porifera Porifera - chemistry South China Sea Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Tumor cells Vascular endothelial growth factor vascular endothelial growth factor receptor-1 Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular endothelial growth factor receptors VEGFR-1 Vimentin Vimentin - metabolism |
| title | Meroterpenoids from Marine Sponge Hyrtios sp. and Their Anticancer Activity against Human Colorectal Cancer Cells |
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