Factors affecting bone maturation in Chinese girls aged 4-8 years with isolated premature thelarche

In isolated premature thelarche (IPT) girls, bone age (BA) is considered consistent with chronological age. However, some IPT girls confirmed by gonadotropin-releasing hormone (GnRH) stimulation test could show another trend. We analysed BA and possible potentiating factors in a selected group of gi...

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Bibliographic Details
Published in:BMC pediatrics 2020-07, Vol.20 (1), p.356-356, Article 356
Main Authors: Su, Huiping, Su, Zhe, Pan, Lili, Wang, Li, Xu, Zhongwei, Peng, Gang, Li, Xianglei
Format: Article
Language:English
Subjects:
Age
Analysis
Body Mass Index
Bone maturation
Child
Child, Preschool
China - epidemiology
Dehydroepiandrosterone
Dehydroepiandrosterone sulfate
Expected values
Female
Gonadotropins
Humans
Insulin
Insulin-like growth factor-1
Insulin-like growth factors
Obesity
Ovaries
Overweight
Pediatrics
Pituitary hormones
Premature thelarche
Puberty
Puberty, Precocious - diagnosis
Regression analysis
Retrospective Studies
Risk factors
Sex hormones
Sulfates
Ultrasonic imaging
Variables
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Summary:In isolated premature thelarche (IPT) girls, bone age (BA) is considered consistent with chronological age. However, some IPT girls confirmed by gonadotropin-releasing hormone (GnRH) stimulation test could show another trend. We analysed BA and possible potentiating factors in a selected group of girls aged 4-8 years with IPT. IPT girls confirmed by GnRH stimulation test aged 4-8 years hospitalized from January 2015 to April 2018 at Shenzhen Children's Hospital were included in this retrospective study. They were divided into two groups with advanced BA of 2 years as the cut-off. Body mass index (BMI) and hormone levels were the main outcome measures, and regression analysis was used to identify independent risk factors. IPT girls were divided into subgroups according to the levels of BMI standard deviation score (SDS), insulin-like growth factor-1 (IGF-1) SDS and dehydroepiandrosterone sulfate (DHEAS) SDS for comparisons of advanced BA. Overall, 423 subjects were included and classified into the advanced BA group (48.7%, n = 206) and control group (51.3%, n = 217). The advanced BA group had significantly higher BMI SDS, serum DHEAS SDS, IGF-1 SDS, androstenedione and fasting insulin and significantly lower sex hormone binding globulin (all p 
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-020-02256-w